Louis Winthorpe III (Dan Aykroyd) sees a Colt Commander with pearl grips at a pawn shop, then buys it. He uses it to threaten Billy Ray Valentine (Eddie Murphy), then, later, try to commit suicide, only for it to misfire, but fire by itself when he throws it away.
When Winthorpe and Billy Ray join together to take down Randolph Duke (Ralph Bellamy) and Mortimer Duke (Don Ameche) for wrecking their lives with a simple bet, Winthorpe takes out several 12 Gauge Double Barreled Shotguns, planning to shoot the Dukes' knee caps.
Clarence Beeks (Paul Gleason) draws an Astra Constable on Winthorpe when he realizes he is in disguise and holds it on Ophelia (Jamie Lee Curtis) before he is knocked unconscious by a caged gorilla and has it taken away by Coleman (Denholm Elliott).
