Fugitive killer Al Walker (William Holden) carries a snub-nosed Smith & Wesson Military & Police revolver, the precursor to the Smith & Wesson Model 10. Walker keeps his 2"-barreled revolver in a shoulder holster.
Al's two henchmen, Mike (Berry Kroeger) and Pete (Robert Osterioh), carry first-generation Colt Detective Special snub-nose revolvers. Frank Stevens (Wilton Graff) takes Mike's Detective Special away from him after attacking him with a fireplace poker.
Colt Official Police
Al recalls a painful memory from his youth where his father had carried a Colt Official Police revolver that a young Al had picked up off the ground.
Smith & Wesson Military & Police (5" Barrel)
The state troopers that descend on the Collins household carry Smith & Wesson Military & Police service revolvers with 5" barrels.
Rifles
Winchester Model 53
Dr. Andrew Collins (Lee J. Cobb) owns a lever-action hunting rifle that appears to be a Winchester Model 53, which he lends to his colleague Professor Fred Linder (Steven Geray). After Professor Linder brings it back to the Collins home, Al Walker (William Holden) briefly handles it as well.
Winchester Model 1907
As in Blind Alley, the primary rifle handled by the criminals is a Winchester Model 1907 semi-automatic rifle with a five-round magazine. Mike (Berry Kroeger) handles the weapon for most of the movie, eventually tossing it to Al Walker (William Holden) to use for the final scene though both Dr. Collins (Lee J. Cobb) and Betty (Nina Foch) handle it as well.