An American Derringer Model 1 can be seen in the armory belonging to the hunter Olivia Lowry (Audra Ricketts) in "Are You There, God? It's Me, Dean Winchester" (S04E02).
A Colt Double Eagle variant can be seen in the armory belonging to the hunter Olivia Lowry (Audra Ricketts) in "Are You There, God? It's Me, Dean Winchester" (S04E02). It is only seen at a distance so the exact model (fullsize, Commander or Officer) is hard to determine).
The custom Heckler & Koch USP Match which originally appeared in Blade II is in the armory belonging to the hunter Olivia Lowry (Audra Ricketts) in "Are You There, God? It's Me, Dean Winchester" (S04E02).
A Taurus Judge can be seen in the armory belonging to the hunter Olivia Lowry (Audra Ricketts) in "Are You There, God? It's Me, Dean Winchester" (S04E02).
A Smith & Wesson Model 686 can be seen in the armory belonging to the hunter Olivia Lowry (Audra Ricketts) in "Are You There, God? It's Me, Dean Winchester" (S04E02).
"The Colt" (Colt Paterson 1836 cartridge conversion)
"The Colt" appears in the time travel episode "In The Beginning" (S04E03) and is in the possession of a young Daniel Elkins (Andy Nez) before being borrowed by Dean (Jensen Ackles).
"Back in 1835, when Halley's Comet was overhead, same night those men died at the Alamo, they say Samuel Colt made a gun. A special gun. He made it for a hunter. A man like us, only on horseback. Story goes, he made thirteen bullets. This hunter used the gun a half dozen times before he disappeared, the gun along with him... Somehow Daniel got his hands on it. They say... they say this gun can kill anything."
The pistol which is simply referred to as "The Colt" is a modified Colt Paterson 1836, first seen in Season 1. The actual gun appears to be built from a Pietta "Paterson Extra Deluxe" based on the engravings and silver inlay markings. The pistol is further modified with a cartridge conversion, by having a pentagram carved into each grip plate, and the barrel is engraved with "non timebo mala" which translates to "I will fear no evil" (a reference to Psalm 23).
Side by Side Sawed Off Shotguns are one of the most common weapons on the show, normally being used by the brothers whenever they are hunting ghosts. They are said to be loaded with rock salt shells due to the fact that spirits are repelled by salt.
A sawn off Ithaca 37 is used by the brothers on several occasions, most commonly when hunting ghosts loaded with rock salt shells. It is also commonly used as a prop to hold open the lid of the weapons compartment in the trunk of the Impala.
A custom Ithaca 37 "Stakeout" with a chrome finish on the barrel and magazine tube and an MP5K style pump is used by the hunter Olivia Lowry (Audra Ricketts) in "Are You There, God? It's Me, Dean Winchester" (S04E02). The exact same weapon can also be seen in House of the Dead and Painkiller Jane.
A Heckler & Koch MP5K can be seen in the armory belonging to the hunter Olivia Lowry (Audra Ricketts) in "Are You There, God? It's Me, Dean Winchester" (S04E02).
What appears to be an M16A2 can be seen in Bobby's safe room in "Are You There, God? It's Me, Dean Winchester" (S04E02). The scene is very dark and the rifle is only briefly seen so this ID is not certain, however the round A2 handguards are visible.
Defense Technologies/Federal Laboratories launcher with folding stock - 37mmError creating thumbnail: File missingThe DefTech is visible in "Yellow Fever" (S04E06), along with a number of what appear to be HE grenades (which are incapable of being fired from 37mm launchers such as the DefTech.
