LAPD Sergeant Jack Colt (Emilio Estevez) carries a Beretta 92FS, drawing it in almost every scene of the film. Anytime he is shown drawing the weapon, the sound of a slide being pulled is played to mock other action films. Colt's character appropriately carries the Beretta 92FS as he is almost a direct parody of Mel Gibson's Beretta-carrying character of Martin Riggs in Lethal Weapon and its sequels.
General Mortars' chief henchman Mr. Jigsaw (Tim Curry) keeps a Wildey Magnum as his primary sidearm throughout the film.
Ruger Mk I
Mr. Jigsaw (Tim Curry) uses a suppressed Ruger Mk I to assassinate LAPD Sgt. Billie York (Whoopi Goldberg) in her home. It is identified as a Mk I by the simple rear sights.
Ruger Mk II Long Barrel
Destiny Demeanor (Kathy Ireland) has a long-barreled Ruger Mk II that she uses when she confronts General Mortars.
M1911A1
General Curtis Mortars (William Shatner) carries a M1911A1 with custom grips as his main sidearm.
Desert Eagle
A robber fires a stainless Desert Eagle in .357 during the convenience store shootout.
Glock 19
The FBI agent on the third floor (Paul Gleason) holds a Glock 19 while telling Colt and Luger to leave.
Smith & Wesson 639
One of the FBI agents walking a suspect out of the third floor has a Smith & Wesson 639 with wood grips.
Revolvers
Smith & Wesson Model 15
After an LAPD officer (Corey Feldman) fires his Smith & Wesson Model 15 at the "domestic dispute". Sgt. Wes Luger (Samuel L. Jackson) takes it from him, saying he'll hand it back when he listens to orders. Several other officers carry them, including Larry Wilcox as he reprises his role as Officer Jon Baker from CHiPs.
The two thugs holding up Halim's convenience store during the opening shootout each have a sawed-off Remington 870s with barrel ribbing.
Ithaca 37
When Luger tells Colt he believes they are being "followed", two masked men with Ithaca 37 shotguns are seen in their back seat.
Submachine Guns
M1928 Thompson
At some points during the convenience store shootout, one of the robbers fires a M1928 Thompson at Colt.
Heckler & Koch MP5A3
Several of the LAPD SWAT officers at the scene of the domestic dispute have Heckler & Koch MP5A3 submachine guns pointed at the apartment.
Uzi
The hoodlums having the "domestic dispute" fire an Uzi at the police below when Luger tells them to "drop their hands and come out with their weapons up". Jigsaw (Tim Curry) is seen later firing an Uzi at Colt and Luger inside the cocaine cookie factory. In a deleted scene, Colt shouts (after he is wounded by Jigsaw) that "It takes more than twelve rounds from an Uzi to kill Ted Zickleman" before realizing someone has taken over his body.
Rifles
FN FAL 50.61
Colt (Emilio Estevez) fires several rounds from an FN FAL at the robbers during the convenience store shootout, which knocks them flying through the window of the store.
MGC CAR-15
Spoofing Sylvester Stallone in the Rambo series, Colt (Emilio Estevez) prepares to attack the cocaine cookie factory with several weapons, including a Japanese replica MGC CAR-15 with a 30-round magazine, but falls over due to the weight. It is identified as an MGC CAR-15 due to the metal buttstock, distinctive handguard ring, blued magazine and the fact that the buttstock is fixed in the halfway extended position.
A helicopter gunner, mocking the scene from Lethal Weapon 2, fires a Heckler & Koch HK21 at a trailer. After the trailer blows up, Bruce Willis walks out in a dirty undershirt (similar to his character in the Die Hard series) and complains.
Other
M72 LAW
One of the robbers during the convenience store shootout fires a M72 LAW.
Flamethrower
The clerks' translator at Halim's convenience store fires a burst from a flamethrower at Colt and the robbers. It seems to be an M2 that the actor is holding it sideways.
M67 hand grenade
Colt (Emilio Estevez) attaches an M67 hand grenade to his tactical clothing when preparing to take on the cocaine cookie factory.