In the opening scene of the film, a Colombian Army soldier is seen questioning John Smith (Brad Pitt) and then Jane Smith (Angelina Jolie) as to whether they are traveling alone while carring a Smith & Wesson Gas Gun grenade launcher.
Ruger 10/22 (air gun)
While John (Brad Pitt) and Jane (Angelina Jolie) are at the fair, John lets Jane try out a game in which a gas powered Ruger 10/22 fires pellets at moving targets. After Jane does a horrible job (firing from the hip), John tries and hits all but the last target. Unable to hold in her true talent, Jane goes again and takes out all the targets in seconds.
Ruger Mk III
During the poker game, John (Brad Pitt) pulls out an integrally suppressed Ruger Mk III pistol with a stainless barrel and blued frame along with a suppressed Browning Buckmark Camper to kill the other players.
Browning Buckmark Camper
John (Brad Pitt) also draws a Browning Buckmark Camper pistol with a suppressor, stainless barrel upper, and black polymer lower during the poker game.
SIG-Sauer P229
John (Brad Pitt) takes out a suppressed SIG-Sauer P229 when he first discovers Jane (Angelina Jolie) is a spy and accidentally shoots out her car windshield with it when he trips through a wooden fence. The gun is not an Equinox as last claimed, it simply has the K-Kote finish polished on the slide to a glossy shine.
SIG-Sauer P226
John (Brad Pitt) uses a SIG-Sauer P226 with a K-Kote slide and a nickel frame when he invade's Jane's (Angelina Jolie) workplace. It can also be seen in his armory under the garage.
Colt M1911A1 XSE
John (Brad Pitt) retrieves a customized Colt M1911A1 XSE from behind a Battleship game board and threads a suppressor on it when he and Jane (Angelina Jolie) face off in the house. Sometimes, as many as 10 shots are heard being fired from his gun, when the maximum capacity of his magazines is eight plus one in the chamber.
Heckler & Koch G36C
When John (Brad Pitt) is talking to Eddie (Vince Vaughn) after finding out his wife's an assassin, a Heckler & Koch G36C can be seen leaning against a wall in Eddie's house. Another can be seen wielded by one of the company men in the KostMart shootout.
Mossberg 500
While John (Brad Pitt) is sorting through the incinerator from Jane's (Angelina Jolie) office at Eddie's (Vince Vaughn) place, Eddie can be seen pacing nervously about with a Mossberg 500 shotgun, chambering it when his mother calls to him from off-screen.
Heckler & Koch MP5K
During the freeway car chase the "Company Men" in the three gray BMWs carry and fire Heckler & Koch MP5Ks. John (Brad Pitt) is seen firing one throughout much of the department store shootout as well.
Two Company Men are seen firing Heckler & Koch MP5A3s with Navy trigger groups, tri-rails, and C-More red dot sights.
Heckler & Koch UMP-45
Jane (Angelina Jolie) uses a Heckler & Koch UMP-45 fitted with a sound suppressor, a C-More red dot sight, a dual magazine clamp, and a vertical foregrip, taken from John's armory under the garage. She ends up triggering a gas explosion when she fires it into the kitchen and ignites fumes from a gas line John had torn open. Despite the UMP-45 having the slowest rate of fire in the UMP series, the sound of the gun firing is much faster than the gun is.
As John and Jane face off in the living room, Jane pulls a Beretta 92G Elite II from the fireplace.
Heckler & Koch USP Elite
John (Brad Pitt) retrieves a Heckler & Koch USP Elite from a box in the garage when the Company Men attack their house, with the intent on using it before Jane (Angelina Jolie) takes it, not wanting to use the "girl gun". Both of them use it later during the car chase. One is also seen in John's garage armory (likely the same gun), but since Jane stole all those guns and he retrieves it from another hiding spot, it is likely a different gun in the film. Based on the muzzle diameter, it appears to be the .45 ACP version.
Heckler & Koch P7M13
Heckler & Koch P7M13 pistols (both nickel and blue) are seen among John and Jane's hidden arsenals.
NAA Guardian
In the restaurant scene John (Brad Pitt) sits down with Jane (Angelina Jolie), she lays one of her custom NAA Guardians down on her lap and covers it with a napkin. When they are dancing, Jane pulls a custom Guardian from John's ankle hoslter.
What looks like an MG34 machine gun is seen in Eddie's mom's house.
Unknown AR-15 Variant
An Unknown AR-15 rifle is seen in Eddie's mom's house, with a flat-top reciever and a 20" flat barrel. It has no open sights.
Browning M2HB
A Browning M2HB is seen in Eddie's mom's house. Why he would need a 120lb machine gun lying around is unknown, since it is doubtful he would pick it up and use it should someone attack his home.
M4A1 Carbine
The "Company Men" in both the hotel raid and the final department store firefight carry M4A1 Carbines.
Hes got a couple more on the left side as well, the bottom has a sight on the rail, too. The Winchester
Type 69
During the final shootout in the department store, at least one of the "Company Men" can be seen carrying and then firing an Type 69 with an optical sight at the Smiths. An RPG-7 can also briefly be seen leaning against Eddie's stove when John Smith first comes to speak with him about his wife. It is clearly a Type 69 due to the iconic heat guard and only has one pistol grip
KTR-03S
In the desert scene, Jane (Angelina Jolie) shoots John (Brad Pitt) in the chest with a KTR-03S that is equipped with an Aimpoint M68 sight and a forward grip. The KTR-03S is built by Krebs Custom Guns and based on the Russian Saiga receiver.
R-47 Widowmaker
In the desert scene when Jane (Angelina Jolie) is waiting for her target to enter the kill zone, she sees an intruder, whom she later discovers is her husband John. Her scanner identifies the rocket launcher he is carrying as the fictional R-47 Widowmaker rocket launcher. After Jane shoots John in the chest (non-fataly hitting his bullet proof vest), he fires this heavily-customized rocket launcher and destroys the shed she is hiding in.
It is wrong to identify this rocket launcher as an M136 AT4 since the AT4 wasn't even used in the construction of this fictional weapon. It was a 100% custom made prop, utilizing design elements and color schemes from the M136/AT4 launcher, but (a) it is a dual pistol grips and shoulder rest pad, (b) the front and back ends have futuristic caps and flanges that look nothing like an AT4 and (c) the overall diameter of the launcher is much larger than the 84mm of the AT4. It is more like a 105mm tube and is roughly the same size as Brad Pitt's head. Enough of the launcher is different to indicate that no AT4 was used and a Hollywood prop shop created the R-47 Widowmaker from scratch.
Smith & Wesson Centennial
In the basement John (Brad Pitt) pulls a Smith & Wesson Centennial .357 magnum out of a toy train box and gives it to Jane (Angelina Jolie) who is displeased she got the smaller "girl" gun. John trades her, giving her the USP Elite and he uses the Centennial while exiting the basement. A continuity error is that, in the shot of then coming through the trap doors, Jane is carrying the revolver with John carrying the USP, but in the following shot, the characters have their appropriate guns.
M67 Hand Grenade
While fleeing from the company men in the Colemans' minivan, John (Brad Pitt) accidentally pulls the pin on a company mans' M67 hand grenade, kicking the luckless thug back into his car where the resulting explosion destroys the armored BMW.
Unknown Grenade
John (Brad Pitt) keeps several unknown grenades in his armory and has two stuck his tac-vest when capturing Benjamin Danz (Adam Brody).
Company Men throw Smoke Grenades (make unknown) into the Smiths' house, which emits green smoke.
Benelli M3 Super 90
During the KostMart shootout John (Brad Pitt) picks up a Benelli M3 Super 90 off one of the Company Men he kills. After running into the elevator, the gun dissappears and is replaced by an MP5A2, do to necessary scenes being cut from the film.
In the KostMart shootout, Jane briefly fires an Unknown Pistol fitted with a C-More sight but ditches it after leaving the supplies shed. It might be a Smith & Wesson auto.
M14 EBR
Jane takes a M14 EBR with a Sage Stock, sound suppressor, and M68 Aimpoint scope off a dead Company Man and uses it to provide cover from the ceiling for John during the battle in KostMart.
Beretta 92FS
While John is playing poker in a back room waiting on "Lucky". The bad guy John disarms while playing poker with him, is carring a Beretta M92F.
TJ's Custom Gunworks Stealth-1
On the film poster, Jane Smith (Angelina Jolie) is seen with a TJ's Custom Gunworks Stealth-1 stuck in her garter belt, which was originally in the film, but was ultimately cut.
Unknown 1911 Varient
On the film poster, John Smith (Brad Pitt) is seen holding an unknown 1911-type pistol. It is NOT the Colt XSE he used in the film as previously claimed. The shot is reversed in older posters (and this screencap) but is correct on the DVD cover.