DEA Agent Sean Vetter (Vin Diesel) and his partner DEA Agent Demetrius Hicks (Larenz Tate) both use a DEA issue 2nd Gen Glock 17 pistol throughout the film. Some cartel thugs also carry the Glock 17 Gen 2.
Beretta 92FS
Agents Vetter and Hicks enters Memo's lair at the beginning PJF raid with a Beretta 92FS given to them to use by one of the Mexican PJF Agents. Garza (Emilio Rivera) uses a Beretta 92FS as his sidearm during the film. It is used frequently by other characters in the film, including Mateo Santos (Juan Fernandez)
Colt Python
A female cartel soldier uses a Colt Python snub nose during the drug deal gone bad shootout.
"Non Gun" revolver
One of the revolver during the shootout is actually a revolver Non Gun.
Smith & Wesson Model 60
Vetter is seen making a suspect play Russian roulette with his nickel Smith & Wesson Model 60.
One of the cocaine factory guards strolls around with an M16A2.
Colt Model 635 9mm
DEA Agent Vetter (Vin Diesel) is seen using the Colt Model 635 with mags taped together "jungle" style in a drug deal gone bad.
Heckler & Koch G3A3
Some of Memo's guards at his place in Mexico are armed with Heckler & Koch G3A3's.
FN FAL
Some of the mercenaries who assault the C-130 cargo plane filled with cocaine are armed with 18" barreled FN FAL's.
AKMS
The AKMS rifle is used throughout the film by cartel soldiers and assassins.
AKMSU
Another weapon seen in the film is a customized AKMSU carbine, wielded by one of the cartel members.
AR-15 Carbine
One of the mercenaries hitting the C-130 is using an AR-15 Carbine.
M4A1
An undercover officer is briefly seen wielding an M4A1 near the film's end.
Submachine Guns
Heckler & Koch MP5SD
The Mexican PJF Agents are armed with the Heckler & Koch MP5SD during the opening raid.
Heckler & Koch MP5K
An undercover officer holds a Heckler & Koch MP5K during the drug bust gone bad.
Uzi
One of the mercenaries hitting the C-130 is using an Uzi.
Micro Uzi
The Micro Uzi submachine gun is briefly seen in the hands of a drug lab guard as well as a female cartel assassin.
Franchi LF-57
A nickel-plated Franchi LF-57 submachine gun with the stock removed is briefly seen wielded by a cartel assassin.
Smith & Wesson M76
A Smith & Wesson M76 submachine gun is briefly held by a mercenary that helps take over a drug lab.
Shotguns
Remington 870 Folding Stock
One of the Mexican PJF Agents uses a Remington 870 Folding Stock with a side shell-storing plate on the receiver. Vetter also uses an 870 with a topfolding stock and shell carrier as well as a forward pistol grip.
Mossberg 500
Memo's Bodyguard carries a sawed-off version of the Mossberg 500 that Vetter strips him of and holds on Memo.
Other
Hand Held M134 Minigun
Big Sexy (George Sharperson) is seen entering a bar armed with an M134 Minigun. Note that while it has a chainsaw grip like the one seen in T2, the grip appears to be thinner.