Fox Mulder (David Duchovny) carries a SIG-Sauer P226. Mulder carried the P226 for the entirety of the show from Season 2 onwards, with the exception of Season 3, when he and Scully both used Smith & Wesson 5906s.
Dana Scully (Gillian Anderson) carried a SIG-Sauer P225 rather than the P228 she used normally. This might have occurred because the show's armorer was unable to bring a P228 on-set for those particular episodes. Scully used the P225 from "Unruhe" (S4E02) until "The End" (S5E20). Walter Skinner (Mitch Pileggi) also occasionally carried a P225.
Fox Mulder carries a Walther PPK in an ankle holster when he loses his SIG-Sauer P226 during "Paper Hearts" (S4E10). This gun was seen previously as Mulder's backup pistol in Season 3's "Nisei" and "731".
In the episode "Terma" (S4E09), a number of Russian guards on horseback are seen armed with Makarov PM handguns as they shoot at Mulder while he is escaping the Tunguska gulag.
Dana Scully uses the Smith & Wesson 5906 handgun that she used in Season 3 in the Season 4 premier episode "Herrenvolk" (S4E01).
NOTE: Several users have suggested that these pistols might be the Smith & Wesson 1076 in 10mm, which was briefly used by the FBI. This is incorrect; the 1076 has a single-stack frame, while the pistols in the show have double-stack frames, meaning that they can only be the model S&W 5906. The show's guns are not the .40-caliber model 4006, because the 4006's frame features checkering on the grip, missing on the show's Smith & Wessons (the 5906 frame has vertical grooves on the grip). The model S&W 1076 can be easily distinguished from the S&W 5906, as the 1076 is hammerless, has no manual safety and a frame mounted de-cocking lever. This is a TV show, not real life, and movie/television armorers have always tended to use 9mm pistols rather than larger calibers, because 9mm blanks are more reliable to cycle in pistols than larger calibers.
In a dream during "Paper Hearts" (S4E10), Fox Mulder grabs his father's revolver from a box. This is the same revolver he attempted to use to save his sister Samantha from alien abduction as a child, seen during Season 2's "Little Green Men" (S2E01).
The M16A1 rifle was used on a regular basis throughout The X-Files run as either a military and/or SWAT weapon. M16A1 rifles are used by the militia gunmen and several FBI agents in the episode "Tunguska" ((S4E08).
Error creating thumbnail: File missingThe butt of the rifle used by the Cigarette-Smoking Man to assassinate Martin Luther King ("Musings of a Cigarette-Smoking Man" (S4E07))Error creating thumbnail: File missingThe rifle used by the Cigarette-Smoking Man to assassinate Martin Luther King ("Musings of a Cigarette-Smoking Man" (S4E07))Error creating thumbnail: File missingThe rifle used by the Cigarette-Smoking Man to assassinate Martin Luther King ("Musings of a Cigarette-Smoking Man" (S4E07))
Ruger Super Redhawk (mocked up to resemble the KAC silent revolver rifle)
The third rifle is what appears to be a Ruger Super Redhawk .44 Magnum mocked up to resemble the KAC silent revolver rifle. This is a long barreled pistol has a carbine length bull barrel, and a bipod and black synthetic buttstock. The rifle has appeared in movies and television shows filmed in Canada including Another Stakeout and Psych. It was previously used in the X-Files by an FBI sniper in the Season 1 episode "Lazarus" (S1E14)
Error creating thumbnail: File missingThe Cigarette-Smoking Man aims at Frohike ("Musings of a Cigarette-Smoking Man" (S4E07))Error creating thumbnail: File missingThe Cigarette-Smoking Man cocks the hammer of his rifle ("Musings of a Cigarette-Smoking Man" (S4E07))Error creating thumbnail: File missingAnother view of the rifle ("Musings of a Cigarette-Smoking Man" (S4E07))Error creating thumbnail: File missingThe rifle the Cigarette-Smoking Man aims at Frohike is in the background, on its tripod. You can see the basic shape of the Ruger under all the 'rifle attachments'. ("Musings of a Cigarette-Smoking Man" (S4E07))Error creating thumbnail: File missingThe Cigarette-Smoking Man aims at Frohike towards the end of the episode ("Musings of a Cigarette-Smoking Man" (S4E07))
Submachine guns
MP5A3
Dana Scully (Gillian Anderson) uses an MP5A3 with an attached flashlight during the FBI raid on the militia in "Tunguska" (S4E08)
Fox Mulder (David Duchovny) uses an unkown shotgun with a pistol grip and mounted flashlight during the FBI raid on the militia group in "Tunguska" (S4E08).
