The American Derringer DA 38 appears in game as the "Swiss Derringer." It is the weapon of choice for antagonist Blake Dexter's crippled son, Lenny "The Limp." It can be collected and used by Agent 47 in Contracts mode.
The AMP Auto Mag Model 180 appears in game as the "SA .44 Auto," and is the preferred weapon of psychopathic henchman Wade. A spider engraving is found on its handle, indicating it is Wade's personal weapon. 47 uses it at his starting weapon in the level "Birdie's Gift". It is also available in Contracts mode, where is starts out with a suppressor. This coupled with its greater damage and range, make it a decent alternative to the Silverballers.
Agent 47's custom AMT Hardballers (often referred to as the "Silverballers") makes a re-appearance in the game. In the storyline mode, the Silverballers are always suppressed and dual wield; with the player having the freedom to toggle between dual or single and suppressed or unsuppressed. The Silverballers can be customized in the Contracts mode with upto three modifications simultaneously.
A snub nose Colt King Cobra appears in the game as the "Mustang Snub". A special nickel plated version belonging to the corrupt sheriff of Hope, Skurky, is also present in the game. It has a sheriff's star on its wooden grip. This version cannot be collected during normal gameplay and has to be purchased in game for use in Contracts mode.
The SIG-Sauer P226R. Called the "Jagd P22G" ingame. The base variant is nickel plated with wooden grips. A suppressed unit can be found in the Vixen club. Blake Dexter's secretary, Layla, carries a custom version that has soft gold plating upon the base scheme. If collected and used in Contracts mode, it will be equipped with a soft gold toned suppressor as well. The third version, is a highly modular version issued by the Agency to its operatives. This version is dark gun metal gray with yellow accents. It can be acquired and modified for the Contracts mode as a DLC, collected in the storyline or purchased ingame.
The Smith & Wesson Model 64 appears in game as the "Z&M Model 60". It is one of the preferred weapons of the Chicago PD, along with the Taurus 24-7. Blake Dexter's henchmen at the Terminus Hotel are all armed with it as well.
The Sphinx 3000 appears as the "Swiss 3000" and has an incorrect 10-round magazine. The Agency also issues a custom version which is carried by a limited number of its operatives, including Benjamin Travis's secretary Jade. Travis himself carries an unique version that has yellow grips with a soft gold plating. Travis's personal sidearm cannot be acquired during the storyline and has to be purchased ingame for use in Contracts mode.
Taurus PT 24/7's with stainless steel slides can be seen used by Chicago Police Officers. However Chicago PD are only allowed to use models from Beretta, Glock, Ruger, Smith & Wesson, or Springfield Armory and those firearms must be chambered 9mm, .40 S&W, or .45 ACP.
The Taurus Raging Bull is called the "Aries Charging Ram" in-game. Special variants with pink grips and one called "The Absolver" can be collected, but the damage of the three weapons is the same. "The Absolver" is available for use in Contracts mode and features the ICA's logo on its grip.
The Brügger & Thomet AG SPP appears in game as the "Zug TMP." Its low damage is balanced out by its high rate of fire and ability to be dual wielded. It can be collected and used in Contracts mode, where it starts out with a suppressor.
A UMP45 appears as the "HX UMP" and is used by Chicago PD in the first act of the game. The Agency's version, called "Agency HX UMP" can be acquired and customized with a plethora of parts for use in Contracts mode. It is distinguished from the base version with its yellow accents. The Agency version isn't found in the storyline and must be bought as a DLC or purchased ingame.
The ST Kinetics CPW. Exclusively issued by the Agency, with the controversial hitsquad, The Saints, being notable users. Colored black with yellow accents and ICA markings. Can be acquired for and modified in the Contracts mode.
The AKMSU appears in game as the "AH 74U" with no S in its name. It is the preferred weapon of antagonist Blake Dexter's factory security guards. Can be collected and used in Contracts.
The Beretta ARX-160 is featured in the game as the "ARZ 160". An Agency exclusive weapon, colored black and yellow with ICA markings. Can be acquired and modified in Contracts mode.
The Franchi SPAS-12. Called the "SPS 12" ingame. The base version can be found in Blake Dexter's Chicago penthouse. A customizable Agency version can be acquired for use in Contracts mode from the storyline, bought as a DLC or purchased ingame.
A Mossberg 590 with ghost ring sights and wood furniture is seen in a screenshot. The base version has wooden furniture. A well wornout tactical version is also present. An in mint condition tactical version, suffixed "Police" can be collected in the storyline and used in the Contracts mode. A suppressed Police version can be found in Blake Dexter's Chicago penthouse, while the weapon starts out suppressed in Contracts mode; making it the only suppressed shotgun in the game.
The Sako TRG-42 appears in the game as the "Kazo TRG". Three versions can be found in game. The basic version is dark green with a brown cheekpiece. Notably Agent 47 starts out the epilogue mission with this weapon in tow. A lighter (by weight) black version can be found in the posession of an Agency sniper in Hope and a suppressed version of the same in Lenny Dexter's room in his Chicago penthouse. The third version is called the "Agency Kazo TRG". It is virtually identical to the black version, save for the yellow controls. It is the only weapon available in "Hitman: Sniper Challenge". While not found anywhere in the main storyline, it is unlocked for players having "Hitman: Sniper Challenge" installed, with a code or needs to be bought as a DLC or purchased ingame for use in Contracts mode. The "Agency Kazo TRG" can be modified, with the upgrades unlocked in "Hitman: Sniper Challenge" being carried forward.
The CIS Ultimax 100 Mk.3 is found ingame as the "Ultramax". The standard version can be found in the bunker in the Gunshop level and in Blake Dexter's Chicago penthouse. Dexter himself carries a cosmetically identical version, customized to have a higher rate of fire, higher damage and yet lower recoil. Dexter's Ultramax is usable in Contracts.
