The Beretta 92FS is first seen used by Mercury (Arly Jover) in the nightclub at the beginning of the film. Other characters who use the pistol include a hospital security guard, Officer Krieger (Kevin Patrick Walls) to threaten Dr. Karen Jenson (N'Bushe Wright), and finally seen in a vampires' hands later in the film.
Beretta 92FS-C Compact
Officer Krieger pulls a Beretta 92FS-C on Karen Jenson in an attempt to kill her before he is swiftly disarmed by Blade.
Glock 26
Blade (Wesley Snipes) hands a Glock 26 loaded with silver hollow point bullets to Karen (N'Bushe Wright) to defend herself. She also uses this gun at another point in the film to shoot at one of the familiars Deacon Frost (Stephen Dorff) sends just before she and Whistler (Kris Kristofferson) are captured.
Revolvers
Smith & Wesson Model 686
When Blade (Wesley Snipes) goes to the hospital to finish off Quinn (Donal Logue), several hospital security guards fire at him, one having a Smith & Wesson Model 686. A police officer also appears to be armed with the revolver.
The machine pistol carried by Blade (Wesley Snipes) is a modified MAC-11. Blade used a modified MAC-11 as the firing portion of the hero gun, with a cast MAC-10 shell as the forward portion of the hero gun.
MAC-10
The vampire DJ at the Bloodbath Rave fires at Blade with a MAC-10 before he is taken down.
Sterling L2A3 submachine gun
One of the familiars in the library is seen armed with a Sterling L2A3 submachine gun. Another familiar is seen firing a Sterling L2A3 at Blade, Whistler and Karen Jenson when they made their escape from the vampire library.
Kimel AP-9
The Kimel AP-9 is wielded by several of Frosts's Familiars.
Intratec TEC-DC9
In several scenes, some vampires and familiars can be seen armed with Intratec TEC-DC9s.
Beretta M12
One of the familiars that Whistler (Kris Kristofferson) mows downs in the library can be seen holding a Beretta M12 sub-machine gun as he falls.
Uzi
In several scenes, the vampires and familiars can be seen carrying full size Uzis.
Smith & Wesson M76
After Blade escapes the library a familiar can be seen with a Smith & Wesson M76 very briefly.
IMI Mini Uzi
A Familiar can be seen armed with an IMI Mini Uzi.
IMI Micro Uzi
A familiar can be seen armed with an IMI Micro Uzi at Frost's penthouse before being taken down.
Heckler & Koch SP89
One of the familiars that Blade (Wesley Snipes) fights before meeting his mother, Vanessa Brooks (Sanaa Lathan) is armed with an H&K SP89.
Heckler & Koch MP5K
Towards the end of the film, several vampires and familiars can be seen armed with H&K MP5K.
When Whistler (Kris Kristofferson) rescues Blade (Wesley Snipes), and Karen (N'Bushe Wright) in the vampire library, he is seen using an H&K MP5SD3 to mow down several familiars. The muzzle flash seen here is impossibly large and bright for a suppressed weapon; it's the result of using a mock suppressor can, combined with full-flash motion picture blanks.
When Blade (Wesley Snipes) escapes the hospital with Karen Jenson (N'Bushe Wright), a SWAT officer fires at him with a Heckler & Koch HK33, from a window, but misses. Several vampires are also seen wielding these weapons.
Shotguns
Benelli M3 Super 90
The shotgun that Blade (Wesley Snipes) uses in the film is a Benelli M3 Super 90 with a pistol grip, modified to fire silver stakes, as well as normal ammunition.
Remington 870
The bartender at the karaoke club tries to pull a stainless Remington 870 with a short barrel and a pistol grip on Blade.
Mossberg 590 Mariner
Whistler can be seen using a Mossberg 590 Mariner to fire at several vampires and Familiars running around the lair.
Mossberg 590
Several vampires can be seen with Mossberg 590s towards the end of the film, theirs are equipped with pistol grips, one of which Karen commandeers and uses.