Vince Majestyk (Charles Bronson) is threatened by Bobby Kopas (Paul Koslo) with a ribbed-barrel Winchester Model 1200 shotgun during an early scene of the film, though Majestyk quickly takes it from him and fires at a speaker fitted to Kopas' truck, Majestyk then places the shotgun in the trunk of Kopas' car. Later Majestyk has his own Winchester Model 1200 Ranger on a gun rack in his home, the shotgun lacks the ribbed barrel of the one used earlier but could be the same gun with the barrel switched by the film's weapon master. At one point, he gives the shotgun to Nancy Chavez (Linda Cristal) and asks her if she knows how to use it, to which she naively replies "...just point and pull the trigger, right?". During the film's finale Majestyk uses this shotgun to take down Frank Renda (Al Lettieri) and his henchmen.
During Frank Renda's (Al Lettieri) breakout, both several mobsters and police use 4" Colt Pythons. Wiley (Lee Purcell) has a Python in her car, which Renda takes and uses for the rest of the film. His right-hand man Gene Lundy (Taylor Lacher) also keeps a Python.
During the final gunfight, Majestyk briefly uses a Bolt-Action Rifle of unknown make or model to fire at Renda. He then drops it in favor of a more "hands on" approach switching back to his Winchester Model 1200 Ranger.