The Silence of the Lambs is the 1991 thriller that marked the first appearance of Anthony Hopkins as Dr. Hannibal Lecter. In the film, FBI recruit Clarice Starling (Jodie Foster) enlists Lecter's help in order to track down a notorious serial killer who has kidnapped a US Senator's daughter. Based on the novel by Thomas Harris, the film would win the Academy Award for Best Picture as well as acting wins for both Hopkins and Foster. Hopkins would reprise his role as Lecter in two more films: Hannibal (2001) and Red Dragon (2002).
The following weapons were used in the film The Silence of the Lambs:
FBI recruit Clarice Starling (Jodie Foster) is shown training with and then carrying the Smith & Wesson Model 13. This .357 magnum, 3" barrel revolver was the last issue revolver of the FBI (usually loaded with .38 spl +P .158 gr LHP ammo). When Starling fires her weapon at Buffalo Bill, there is noticeable recoil and she flinches. However, when she fires it on the range in the deleted scenes, there is absolutely no recoil, and she keeps her eyes open. This could indicate multiple weapons were used on set.
Browning Hi-Power
As they close in on Lecter, one of the SWAT officers is seen with a Browning Hi-Power with Target sights before he opens the elevator access panel. Another SWAT officer appears to use a Browning HP to wound a suspect in the leg.
Colt Government
One of the FBI instructors uses a deactivated Colt Government to demonstrate to Clarice and the recruits what went wrong during an exercise.
Colt Python
Jame Gumb a.k.a "Buffalo Bill" (Ted Levine) is seen holding what appears to be a 6" barreled, stainless steel Colt Python with Pachmyr Presentation grips. In the book, it is said that Gumb loads the gun with .38 Special lead wadcutters.
A Heckler & Koch P7M13 is briefly seen in the hands of an FBI HRT agent as Crawford and his men breach the suspected house of Buffalo Bill.
Shotguns
Remington 870
FBI Special Agent Jack Crawford (Scott Glenn) prepares to assault the possible home of Buffalo Bill armed with the Remington 870 shotgun. According to Scott Glenn's commentary on the Blu-Ray edition, the shotgun originally had an 18 inch barrel, but Glenn insisted upon having a shorter one. The armorer explained that making it shorter would not be legal, but finally relented and cut down the barrel down to 14 inches shortly before the scene was shot.
Ithaca 37
Several variants of the Ithaca 37 shotguns are carried by the Memphis P.D. SWAT officers that respond to Hannibal's prison break.
Submachine Guns
Fake Heckler & Koch MP5K
SWAT officers are shown holding what appears to be an Airsoft version of the Heckler & Koch MP5K as they prepare to take down Lecter in the elevator.
Note: This appears to be a FalconToy SoftAir MP5K, based on the "SD"-looking foregrip.
Assault Rifles
M16A1
Soldiers of the Tennessee National Guard were seen armed with M16A1 rifles at Memphis Airport when Dr. Hannibal Lecter arrived in Memphis to assist federal agents. National Guardsmen tasked with guarding Dr. Lecter at the makeshift prison he was incarcerated in were also seen armed with M16A1 rifles.
Rifles
Remington 700PSS
FBI HRT agents close in on the suspected house of Buffalo Bill carrying their Remington 700PSS sniper rifles.