Trinity (Carrie-Anne Moss) carries at least one Beretta 92FS Compact in Reloaded. She draws one and aims at Peresphone (Monica Bellucci) when she desires to kiss Neo (Keanu Reeves). She later pulls the same gun and empties her magazine into one Twin's arm when he blocks open a door leading to a parking garage.
As per the norm in the Matrix series, the Agents can be seen wielding the powerful Desert Eagle pistol. Smith (Hugo Weaving) uses them to terrifying effect when a group of his clones, all carrying identical Desert Eagles, volley fire them at the protagonists as they're trying to flee, fatally wounding the Keymaker (Randall Duk Kim) with multiple hits to the torso.
During the freeway chase scene, one of the Twins opens fire on the protagonists with an H&K UMP fitted with a C-More red dot sight and a seemingly bottomless magazine. Showing no concern for innocents caught in the crossfire, he opens fire on a luckless Chevy Tahoe SUV that winds up between him and his target, causing it to flip and trigger a spectacular chain-reaction pileup.
A Glock 18 can be seen during the protagonists' escape from the Merovingian (Lambert Wilson). First in the confrontation with the Twins in the parking garage, then in the following freeway chase scene, where Morpheus (Laurence Fishburne) uses it to destroy the Twins' Cadillac Escalade after using a katana to help flip the vehicle. Morpheus's Glock 18 is fitted with a standard magazine during the scene in the parking garage, then reloaded with a high-capacity extended magazine during the freeway chase.
While making their way through the hallway of doors, the protagonists have an unexpected encounter with Smith. When he tells them that he "wants everything", Morpheus pulls out a Walther P99 and holds it to his head, asking if "everything" included a bullet from the gun. Before Morpheus can fire, a swarm of Smith clones burst in and overpower him.
After agreeing to help the protagonists, Persephone (Monica Bellucci) kills one of her husband's henchmen and threatens another with a silver COP 357 Derringer with pearl grips, loaded with silver bullets.
During the meeting where the machines' plan to attack Zion is revealed, one of the Zion rebels guarding the door is seen carrying a chrome Mossberg 590 "Compact Cruiser" shotgun with black trigger grip and foregrip.
One of Niobe's (Jada Pinkett Smith) teammates, Ghost (Anthony Wong), packs a stainless steel Sig Sauer P229 Sport. He is briefly seen loading it just before the car he and Niobe are in is rear-ended by a semi truck whose driver has changed into an Agent.
