As in the previous film, RoboCop (Peter Weller) carries the Beretta 93R "Auto 9" as his sidearm of choice. Moreover, he is actually seen reloading the weapon, something rarely shown throughout the films. Another Auto-9 pistol is used by the first malfunctioning RoboCop 2 prototype.
SIG-Sauer P228
Officer Anne Lewis (Nancy Allen) carries a SIG-Sauer P228 as her sidearm throughout the movie, which was a brand-new pistol at the time that RoboCop 2 was made (this is, in all likelihood, the first film ever to feature this gun, because the P228 was first introduced in 1990, the same year this film was made). The P228 can also be seen in the hands of the Little League coach-turned-robber during the incident at the electronics store. A Detroit Police officer is also seen with one during the end battle with RoboCain.
UC-M21
Hob (Gabriel Damon) carries a UC-M21 as his weapon-of-choice throughout the film. This gun was designed by Dave Boatman and based on an earlier version conceived by Eugene Stoner, the Ares FMG. Stoner developed it in the early 1980s as a PDW for high-ranking politicians and wealthy businessmen in kidnapping prone nations. The blue exterior gives the gun the appearance of a plastic lunchbox, in order to fool unsuspecting cops who don't realize that Hob is a young drug lord.
IMI Desert Eagle Mark I
There are several appearances of the Desert Eagle Mark I in the film. The first is during the gun store robbery in the opening, when a drug dealer steals a blued .357 Magnum version and uses it to kill the store owner. The second appearance is in the hands of Hob (Gabriel Damon), who uses a nickel .44 Magnum model to shoot RoboCop in the visor after RoboCop's directives prevent him from shooting a kid, a fact Hob torments him on.
Pauza P50
During the gun store robbery in the beginning, the robbers can be seen taking scoped Pauza P50 long-range .50 caliber semi-automatic sniper rifles from a display case which is specifically marked "Pauza Specialties". Scoped Pauza P50s can be seen in the hands of Cain's (Tom Noonan) thugs twice more in the film - Once when a sniper attempts to shoot RoboCop (but is shot in the eye through the scope from RoboCop's Auto-9 before getting a shot off) and again by one of Hob's men during the shootout when RoboCop 2 (AKA RoboCain) interrupts Hob's meeting with the mayor. RoboCop himself later uses a Pauza P50 without a scope, representing the 'Cobra Assualt Cannon' from the previous film, when he confronts RoboCop 2/RoboCain at the OCP Civic Centrum.
Beretta 93R
An unmodified Beretta 93R (not the Auto 9) is used by one of Hob's thugs during the meeting with the mayor. Another can be seen in the gun store at the beginning of the film.
M136 AT4
During the gun store robbery scene, a drug dealer named Chet (played by Thomas Rosales Jr., who always plays characters in movies who get killed) fires at RoboCop's crusier with an M136 AT4 rocket launcher.
Sterling L2A3
A Sterling L2A3 is seen in the hands of the robber wearing the SAS Beret next to Rosales' character as he prepares to fire the AT4.
Norinco Type 56 (all variants)
Norinco Type 56 AK rifles are a very common weapon used in the film by Cain's (Tom Noonan's) thugs. Nearly every variation of the Type 56 appears in the film, including the fixed stock Type 56, the under-folding stock Type 56-1, and the side-folding Type 56-2. The Type 56 rifles in the film all seem to have some type of unusual flash hider which looks similar to that of the AK-74, and some of the rifles also have Bakelite magazines.
Browning M2 Aircraft
A Browning M2 Aircraft machine gun modified with Crew Served Weapon sight is used by Hob and is used to shoot off RoboCop's gun hand.
Heckler & Koch MP5K
The Heckler & Koch MP5K is another weapon used by many of Cain's thugs. In one scene, RoboCop kills a drug dealer who is using his MP5K to hold a baby hostage.
Intratec TEC-9
One of the thugs at the beginning Nuke lab shootout has what appears to be a Intratec TEC-9. It could also be the similar-looking Kimel AP-9, however the overall look more closely resembles the actual TEC-9 rather than the AP-9, most particularly the straight magazine well (as the one on the AP-9 is slanted).
Calico M950
Another thug at the Nuke lab shootout uses a Calico M950 with 100-round magazine and coverted to full-automatic. It can be differentiated from the standard full-auto M950A by it's lack of a forward pistol handgrip.
MAC-10
A MAC-10 (with unusual extended magazine) is used by one of Hob's thugs in the scene where RoboCop 2 breaks up his meeting with the mayor. Another one is seen in the hands of a Detroit Police officer towards the end of the film.
M16A2
Many of the Detroit Police Officers in the film are seen using M16A2 assault rifles fitted with MWG "90-rounder" inverted drums, though at least a few have 30-round translucent magazines. Like most of the Hollywood "M16A2s", these all have M16A1-style flash hiders (as evidenced by the "starburst" pattern muzzle flash whenever they're fired).
Daewoo K1A1
Some of the Detroit Police Officers use the Korean-made Daewoo K1A1 carbine. Like their M16A2s, these are also fitted with 90-round inverted drum magazines. All of them also seem to have M16-style flash hiders rather than the long, conical flash hider that is more commonly seen on the K1A1.
Steyr AUG
Other Detroit Police Officers can be seen with Steyr AUG A1 assault rifles. Several are fitted with 42-round magazines, just like in the first movie.
Benelli M3 Super 90
Anne Lewis can be seen using a pistol-grip Benelli M3 Super 90 shotgun in the climax when the cops are shooting at RoboCop 2. Several other officers use these shotguns as well.
One of the drug dealers in the gun store robbery can be seen taking and then using an Armsel Striker cylinder shotgun from the store.
Mossberg 500 Mariner
The door guard at the Nuke lab in the beginning of the film grabs a pistol-gripped Mossberg 500 Mariner stainless shotgun with extended magazine tube but is punched out (through the door) by RoboCop before he can use it.
Walther PPK
Cain (Tom Noonan) uses a stainless Walther PPK to kill a woman who was taking refuge in his limo.
Remington 870 (various variants)
Several types of Remington 870 shotgun are used in the film. Angie (Galyn Görg) can be seen using a pistol-grip, sawed-off Remington 870 fitted with a grenade launcher during the shootout at the Nuke plant. Another similar shotgun is used by one of Hob's men during the first RoboCain shootout. A folding-stock Remington 870 shotgun is briefly visible in the hands of a Detroit police officer in the climax. Another standard-stock 870 with extended magazine tube is seen in the hands of one of Cain's thugs at River Rouge.
Remington 1100
A Detroit police officer can be seen with what appears to be a full-sized Remington 1100 with standard stock and extended magazine tube.
RoboCop 2/RoboCain
Like the ED-209, "RoboCop 2" or "RoboCain", the law enforcement droid that Cain's brain is implanted in, contains several heavy weapons.
M134 Minigun
The M134 Minigun is the main weapon of RoboCop 2/RoboCain. The Minigun is seen being fired when RoboCop 2 bursts in on the drug deal as well as when the droid is introduced to the public.
Heavy Caliber Cannon
RoboCain is also armed with large-caliber cannons similar to the ones mounted on ED-209. They're fired at the original RoboCop during the final confrontation.