In the beginning of the film, Blade (Wesley Snipes) kills a familiar, Gedge (Scott Heindl) armed with a Beretta 92FS. One of the police officers that fire at Blade and Nightstalkers as they escape the FBI headquarters also has a Beretta 92FS.
Abigail Whistler (Jessica Biel) carries a Smith & Wesson Model 686, which she nicknames "Lucky7" due to it's 7-shot capacity as her sidearm (A 686 with a 7-shot capacity is designated a Smith & Wesson 686 Plus).
The vampires that try to capture Blade (Wesley Snipes) at the FBI Headquarter are armed with AP-9s, a gun built by AA Arms/Kimel Industries and is commonly confused with the Intratec TEC-9/DC-9s. Danica Talos (Parker Posey) also uses a satin nickel version of the AP-9 when she is shooting at Abigail (Jessica Biel) on the catwalk at the end of the film.
When the FBI raid Blade's (Wesley Snipes) hideout, Whistler (Kris Kristofferson) uses a customized Remington 870 fitted with a heat-shield, a side-saddle shell holder on the receiver in addition to a fabric shell holder on the stock, and a Surefire foregrip; When this gun runs out of ammo, he grabs a second Remington 870 with a high capacity magazine tube and uses that before he is injured.
A new addition to Blade's (Wesley Snipes) arsenal is a WW2 Krieghoff Model L German Signal Pistol, modified with adapters to use 12 ga ammo, modified to fire silver stakes.
Hannibal King (Ryan Reynolds) carries a pair of fictional "Electronic Pistols" that fire "Sun Dogs," explosive rounds that emit a burst of ultraviolet light. A miniature camera is mounted next to the barrel, recording to a disc housed in the rear of the slide assembly.
In the armory, Hannibal (Ryan Reynolds) shows off the Nightstalkers' take on "the Army's Individual Combat Weapon," designed to fire multiple types of ammunition, including silver stakes, UV-explosive rounds, or grenades. The weapon is actually a heavily modified Winchester Model 1887.
The weapon is not used or seen again in the film; however, in the alternate ending featured on the DVD's special features, he fires it when the Nightstalkers track down a werewolf in a Hong Kong casino.
The concept artist for the film, TyRuben Ellingson, refers to the weapon as "the Bone Jack;" during production it was also called "the Mudflap Gun" for the silhouette of Leta Laroe on the stock. The Bone Jack was to have a larger role before being cut; it could fire multiple types of vampire killing ammunition, from the "Sun Dogs" used in other Nightstalker weapons to stakes and grenades.
