Appleseed is a 70 minute one-shot OVA based on the 1985-1989 manga series of the same name written by Masamune Shirow (creator of Ghost in the Shell and Black Magic M-66).
The following firearms are used in the anime OVA Appleseed:
Deunan Knute's sidearm of choice is a Colt MK IV Series 70 .45 caliber pistol. Of all the weapons in the OVA, this one undoubtedly gets the most screentime.
One of the plainclothes officers at the beginning of the OVA is armed with a MAC-11 submachine gun, which he has hidden under a magazine in the back seat of the officers' car.
Briareos Hecatonchires' weapon of choice is a MAC-10 submachine gun. At close to 7 feet tall, Briareos uses the MAC-10 as a machine pistol instead of a full sized submachine gun.
Briareos is seen using an extremely large, high caliber bullpup rifle when Hitomi is kidnapped. This is a fictional rifle that appears several times in the manga and is usually used by LandMates. Given Briareos' size and strength, he is able to use this weapon like a regular assault rifle.
Error creating thumbnail: File missing"That's far enough. Do what I say and this won't go off." Briareos holds an enemy LandMate at gunpoint.Error creating thumbnail: File missing"Alright, hot shot, drop da' girl or I'll fill you so full a' holes you'll be winnin' the next Mr. Swiss Cheese contest. You're really begginin' to piss me off, now drop da' fuckin' girl!" When you're a cyborg with a huge assault rifle, you can give all the cheesy one-liners you want.Error creating thumbnail: File missingBriareos with his rifle. Note that the LandMate behind him is holding the same exact model
Machine Guns
Browning M2
The officers who try to arrest the terrorist at the beginning of the OVA wind up on the business end of a Browning M2HB mounted to an M3 tripod.
During the confrontation with Calon, Deunan uses a M79 grenade launcher outfitted with a red dot scope. Given the fact that she's confronting a LandMate, this configuration doesn't seem as absurd as it would anywhere else.
The LandMates (a halfway point between a mecha and power armor) seen in the OVA use a set of specialized weapons for LandMate-on-LandMate combat. The rifles carried by the ES.W.A.T.'s CADMOS LandMates appear to be simple bullpup rifles reminiscent of the Norinco Type 86, while the industrial LandMates used by the HLU terrorists carry rifles with a conventional LR-300-esque design. All of these weapons have been scaled up to accommodate the larger dimensions of a LandMate and appear to fire large caliber armor-piercing rounds anywhere between 12 to 20mm.