The shotgun the Blade (Wesley Snipes) uses in the film is a Benelli M3 Super 90 with a pistol grip modified to fire silver stakes, as well as normal ammunition.
MAC-11
Blade's (Wesley Snipes) machine pistol is a modified MAC-11.
Blade used a modified Mac 11 as the firing portion of the hero gun, with a cast Mac10 shell as the forward portion of the hero gun. A vampire also fires a regular MAC-10.
Beretta 92FS
The Beretta 92FS is seen several time during this film. First by a female in the nightclub at the beginning of the film, by a hospital security guard, by Officer Krieger (Kevin Patrick Walls) to threaten Dr. Karen Jenson (N'Bushe Wright), and finally seen in a vampires hands later in the film.
Colt Python
When Blade (Wesley Snipes) goes to the hospital to finish off Quinn (Donal Logue), several hospital security guards fire at him, one having a Colt Python.
When Blade (Wesley Snipes) escapes the hospital with Karen Jenson (N'Bushe Wright), a SWAT officer fires at him with a Heckler & Koch HK33, from a window, but misses. Several vampires are also seen wielding these weapons.
Beretta 92FS-C Compact
Officer Krieger pulls a Beretta 92FS-C on Karen Jenson in an attempt to kill her before he is swiftly disarmed by Blade.
Glock 26
Blade (Wesley Snipes) hands a Glock 26 loaded with silver hollow point bullets to Karen (N'Bushe Wright) to defend herself. She also uses this gun at another point in the film to shoot at one of the vampires Deacon Frost (Stephen Dorff) sends just before she and Whistler (Kris Kristofferson) are captured.
Remington 870
The bartender at the karaoke club tries to pull a Remington 870 on Blade.
Heckler & Koch MP5SD3
When Whistler (Kris Kristofferson) rescues Blade (Wesley Snipes), and Karen (N'Bushe Wright) in the vampire library, he is seen using an H&K MP5SD3 to mow down several vampires. The muzzle flash seen here is impossibly large and bright for a suppressed weapon; it's the result of using a mock suppressor can, combined with full-flash motion picture blanks.
Beretta M12
One of the vampires that Whistler (Kris Kristofferson) mows downs in the library can be seen holding a Beretta M12 submachine gun as he falls.
Uzi
In several scenes, the vampires and familiars can be seen carrying full size Uzis.
Smith & Wesson M76
After Blade escapes the library a familiar can be seen with a Smith & Wesson M76 very briefly.
One of the vampires in the library is seen armed with a Sterling L2A3 submachine gun.
Kimel AP-9
The Kimel AP-9 is wielded by several of Frosts's Familiars.
Intratec TEC-DC9
In several scenes, some vampires and familiars can be seen armed with Intratec TEC-DC9s.
Mossberg 590 Mariner
Just before Whistler (Kris Kristofferson) and Karen (N'Bushe Wright) are capture by Frost's (Stephen Dorff) men. Whistler can be seen using a Mossberg 590 Mariner to fire at several vampires and familiars running around the lair.
Mossberg 590
Several vampires can be seen with Mossberg 590s towards the end of the film, theirs are equipped with pistol grips, one of which Karen commandeers and uses.
Heckler & Koch SP89
One of the familiars that Blade (Wesley Snipes) fights before meeting his mother, Vanessa Brooks (Sanaa Lathan) is armed with an H&K SP89.
Heckler & Koch MP5K
Toward the end of the film, several vampires can be seen armed with H&K MP5K.
IMI Mini Uzi
A Familiar can be seen armed with an IMI Mini Uzi.
IMI Micro Uzi
A familiar can be seen armed with an IMI Micro Uzi at Frost's penthouse before being taken down.