The shotgun the Blade (Wesley Snipes) uses in the film is a Benelli M3 Super 90 with a pistol grip modified to fire silver stakes, as well as normal ammunition.
Blade's (Wesley Snipes) machine pistol is a modified MAC-10.
Blade used a modified Mac 11 as the firing portion of the hero gun, with a cast Mac10 shell as the forward portion of the hero gun. A vampire also fires a regular MAC-10.
The Beretta 92FS is seen several time during this film. First by a female in the nightclub at the beginning of the film, by a hospital security guard, by Officer Krieger (Kevin Patrick Walls) to threaten Dr. Karen Jenson (N'Bushe Wright), and finally seen in a vampires hands later in the film.
When Blade (Wesley Snipes) goes to the hospital to finish off Quinn (Donal Logue), several hospital security guards fire at him, one having a Colt Python.
When Blade (Wesley Snipes) escapes the hospital with Karen Jenson (N'Bushe Wright), a SWAT officer fires at him with a Heckler & Koch HK33, from a window, but misses. Several vampires are also seen wielding these weapons.
Blade (Wesley Snipes) hands a Glock 26 loaded with silver hollow point bullets to Karen (N'Bushe Wright) to defend herself. She also uses this gun at another point in the film to shoot at one of the vampires Deacon Frost (Stephen Dorff) sends just before she and Whistler (Kris Kristofferson) are captured.
When Whistler (Kris Kristofferson) rescues Blade (Wesley Snipes), and Karen (N'Bushe Wright) in the vampire library, he is seen using an H&K MP5SD to mow down several vampires. The muzzle flash seen here is impossibly large and bright for a suppressed weapon.
Just before Whistler (Kris Kristofferson) and Karen (N'Bushe Wright) are capture by Frost's (Stephen Dorff) men. Whistler can be seen using a Mossberg 590 Mariner to fire at several vampires and familiars running around the lair.
Several vampires can be seen with Mossberg 590s towards the end of the film, theirs are equipped with pistol grips, one of which Karen commandeers and uses.
A compact pump shotgun with a nickel finish was seen briefly being drawn by the bartender in the club where Blade chases down Officer Krieger. The bartender tries to use this weapon to fire at Blade but it is kicked out of his hand when Blade jumps over the bar.
