Early in the film, Detective Harlan Regis (Wesley Snipes) has to talk down a bureaucrat who is threatening to commit suicide in the middle of an intersection with a stainless Taurus PT945.
Unknown flattop AR variant
In the opening scene of the film, a SWAT sniper is seen with an unknown AR-15 variant which has a flattop receiver with a scope, suppressor, and bipod attached.
Glock 17
Detective Harlan Regis (Wesley Snipes) carries a Gen 2 Glock 17 as his service weapon. All of the other Washington, DC police officers also use Glock 17s. The Glock 17 used by Wesley Snipes in this movie was eventually auctioned off by Heritage Auctions in 2018 (pictures from the listing appear below).
Beretta 92FS Inox
Secret Service Agent Nina Chance (Diane Lane) carries a Beretta 92FS Inox as her weapon of choice throughout the movie, even though this weapon has never been approved for Secret Service use in real life.
SIG-Sauer P226
Many of the Secret Service agents in the movie can be seen using SIG-Sauer P226 pistols as their sidearms, including Daniel Benzali as Agent Nick Spikings, the Chief of White House Security. It seems to be rather common for 1990s action movies to depict Secret Service agents using the P226 as their duty weapons (see also, for instance, Air Force One) even though in real life the P226 has never been used by the Secret Service.
There is an interesting scene in the film where Regis is forced to choose between two P226s when involved in a shootout, one of which is loaded and the other of which is not (he isn't sure which is which).
Mini Uzi
Many of the Secret Service agents use Mini Uzi submachine guns whenever they are on alert, all of which seem to have their side-folding stocks removed for some reason. Although in real life, the Secret Service relied heavily upon the full version of the IMI Uzi (not the Mini version), the Service replaced it in 1995 with the Heckler & Koch MP5. Therefore, the agents should have been equipped with MP5s. When Detective Regis and Agent Chance are in a shootout in Spikings' house with assassins, one of the assassins is also using a Mini Uzi that has been fitted with a suppressor.
Glock 26
In the climax of the film, a Secret Service agent who captures Regis is armed with a Glock 26, another weapon which, like the SIG P226 has never been used by the Secret Service.
SIG-Sauer P228
During the climax, at least one Secret Service Agent is armed with a SIG-Sauer P228, a pistol which was actually used by the Secret Service, unlike nearly all of the other handguns seen in the hands of the agents in the film.
Glock 19
When Regis goes to meet Kyle Neil (Tate Donovan), the First Son, he takes a Glock 19 off of Neil, but later gives it back.
Beretta 92FS
Some of the Secret Service Agents in the film use Beretta 92FS pistols, yet another weapon which has never been issued to the Secret Service. One of the assassins who fights Regis in Spikings' home also uses one.
Unknown AR carbine
During the shootout at Spikings' house, one of the assassins uses an unknown M16 carbine variant with a suppressor and Aimpoint sight which looks somewhat like an XM177E2, but this is not certain.