Vash wields a massive revolver as his main weapon like in the original series. The caliber has apparently been scaled down from .45 Long Colt to .22, based on Vash asking the townsfolk for .22 bullets in "Noman's Land".
Roberto de Niro carries a double-barreled Derringer as his main weapon.
Error creating thumbnail: File missingRoberto holds his Derringer when confronting Wolfwood in "Hungry!".Error creating thumbnail: File missingRoberto and Meryl Stryfe take cover in "Child of Blessing". Interestingly, the Derringer was Meryl's main weapon in the original series, who would carry dozens of them under her coat.
Golden Pistol
Chuck Lee, the captain of the July City Military Police wields a golden pistol with a laser sight as his sidearm in "Noman's Land".
Nicholas D. Wolfwood carries his iconic giant cross-shaped weapon platform called the "Punisher" in the series. The Punisher consists of a machine gun and a laser cannon.
Monev the Gale is armed with two arm-mounted gatling guns like in the original series.
Error creating thumbnail: File missingMonev the Gale aims his gatling guns in "Child of Blessing". The strange devices attached to his guns are air cannons that launch blasts of wind.