The Strayer Voigt Infinity handgun is featured prominently throughout Heroes. The pistol is seen carried by several characters in Season 1, notably Noah Bennet a.k.a. The Man in the Horn-Rimmed Glasses (Jack Coleman), Mr. Linderman (Malcolm McDowell), and Mr. Thompson (Eric Roberts). Essentially, if a character is associated with The Company, there's a good chance they'll be packing this pistol.
LAPD Officer Matt Parkman (Greg Grunberg) carries a police issue Beretta 92FS that he draws in several episodes of Season 1. In "One Giant Leap" (S1E03), Matt uses his Beretta to save FBI Special Agent Audrey Hanson (Clea DuVall) by firing a few shots at Sylar (Zachary Quinto) when he has her gun turned on her, to which the villain gets back up seemingly unharmed. Disguised as a security guard, Ando Masahashi pulls a Beretta on a future version of his friend Hiro in ".07%" (S1E19).
Beretta 8000 Cougar
A Beretta 8000 Cougar is carried by a gaming commission officer in "Unexpected" (S1E16).
Glock 19
In "One Giant Leap" (S1E03), FBI Special Agent Audrey Hanson (Clea DuVall) draws a Glock 19 handgun during a confrontation with Sylar (Zachary Quinto). She tries to arrest him, but the villain uses his Telekinesis to turn her own gun on herself.
Colt Government
In "The Hard Part" (S1E21), Peter Petrelli (Milo Ventimiglia) hands Claire Bennet (Hayden Panettiere) a Colt M1911A1 Government with brown plastic grips and provides her with instructions to shoot him in the head if he is going to explode.
Smith & Wesson 3913
In later episodes of Season 1, Matt carries a Smith & Wesson 3913 as his sidearm.
Revolvers
Smith & Wesson Model 10
In "Better Halves" (S1E06), Ando spots what appears to be a snubnose Smith & Wesson Model 10 with a nickel finish on top of a briefcase owned by Ernie, aka "The Man with the Scary Face".
Smith & Wesson Model 36
A Smith & Wesson Model 36 is carried by a convenience store robber that is thwarted by Matt Parkman in "Hiros" (S1E05). Matt is seen picking up the revolver in the episode. A S&W 36 also is owned by Noah Bennet, which he tries to handle when Matt Parkman and Ted Sprague (Matthew John Armstrong) break into his home, though Ted manages to take it from him.
Submachine Guns
Heckler & Koch UMP
The Heckler & Koch UMP is seen in the hands of tactical operatives in (S1E20).
In the unaired version of "Pilot" (S1E01) a Benelli M1 Super 90 fitted with a pistol grip and Surefire dedicated forend weaponlight is carried by a SWAT officer. A gaming commission officer also is armed with the shotgun.
Rifles
"Kinsella 320Z" (Blaser R93 LRS2)
In "Homecoming" (S1E09), Jessica (Nikki's alternate personality) is seen purchasing a sniper rifle and uses it in an attempt on D.L.'s life. While the dealer identified that the rifle as a "Kinsella 320Z", in reality the rifle is the Blaser R93 LRS2 Sniper Rifle. The dealer also mentions that the rifle can punch a hole through body armor at 400 yards and the price ($2000) she paid for it would not be worth it for the seller.
M4A1
The M4A1 is mainly seen carried by LAPD SWAT in Season 1.