The M1911A1 is one of the most frequently used handguns in the film (mainly Springfield Armory models, which are clearly seen on the slides of the guns). At the beginning of the film, The Man (Josh Hartnett) uses a G.I. model fitted with a sound-suppressor to kill a woman. Marv (Mickey Rourke) also packs a G.I. model, which he affectionatly named "Gladys", after a nun in his catholic school. Apparently he took the gun from a guy he killed at school based on the line "I stole her off the toughest guy I ever messed with, back in school. He was dead at the time, so he didn't miss her." -(graphic novel Sin City: The Hard Goodbye"). Det. Jack "Jackie Boy" Rafferty (Benicio Del Toro) packs a single G.I. model with Pearl grips and Dwight McCarthy (Clive Owen) carries two matching Mil-specs with ivory grips. Along with all of them, several random extras such as thugs and Old Town prostitutes are seen with M1911A1s as well.
Micro Uzi
The Painted Cop (Ryan Rutledge) brings a squad armed, like himself, with Micro Uzis to take out Marv (Mickey Rourke) at the Roark's farm. We later see both an Old Town prostitute and an IRA mercenary with Micro Uzis.
IMI Uzi
Gail's (Rosario Dawson) weapon of choice is a full size 9mm IMI Uzi. The police guarding Cardinal Roark's (Powers Boothe) home also carry IMI Uzis.
Beretta 92FS (mocked up as M93R Auto 9)
Douglas Klump (Rick Gomez) is the first we see with a Beretta M93R Auto 9. Hartigan (Bruce Willis) later takes Klump's Beretta M93R Auto 9 and kills a cop with it at the Roark's farm. Close inspection of the slide reveals a decocking safety of a Beretta 92FS, while a genuine M93R has a frame mounted safety, meaning this gun is a 92FS mocked up as an Auto 9.
Beretta 92FS
Roark Jr. a.k.a. Yellow Bastard (Nick Stahl) packs a Beretta 92FS when he follows Hartigan (Bruce Willis) to Katie's Bar and then fires it at Hartigan and Nancy (Jessica Alba) as they try to escape in her car.
SPAS-12
One of the IRA mercenaries that comes after Dwight McCarthy (Clive Owen) at The Pits carries a SPAS-12.
Steyr AUG
The IRA mercenary that shoots McCarthy (Clive Owen) from the T-Rex uses a Steyr AUG. Later when they find the bullet in Rafferty's badge, the bullet is far too large to be a 5.56mm.
Intratec TEC-9
When Dwight McCarthy (Clive Owen) packs the mob into the twisted alleyway prostitutes open up with Intratec TEC-9s.
Smith & Wesson Model 29
In the beginning of the film, Detective Hartigan (Bruce Willis) uses a Smith & Wesson Model 29 .44 magnum to rescue the young Nancy Callahan (Makenzie Vega), and also uses it to blow Roark Jr. (Nick Stahl) apart. Frank Miller made Hartigan use a .44 magnum as an ode to Dirty Harry and felt the 5th film was a bad way to end the series, so he made this as his Dirty Harry. Note how Nancie's last name is "Callahan." Despite being a lefty in real life, Bruce Willis was nice enough to fake being a righty shooter for the film to stay faithful to the comics.
Colt Python
In the beginning of the film, Bob (Michael Madsen) shoots his partner, Hartigan (Bruce Willis) with a Colt Python in the back and chest in fear of the Roark family's wrath. Marv's parole officer Lucille (Carla Gugino) also packs a Colt Python, but hers is a snub nosed version. A hitman holds a Colt Python to Marv's back in Katie's Bar, and an Old Town prostitute can also be seen wielding one.
Colt 1911 Defender
During the scene were Hartigan (Bruce Willis) is in a hospital room and Senator Roark (Powers Boothe) is telling him how he'll pay for shooting Roark Jr.(Nick Stahl), Senator Roark can be seen with a Colt Defender (a 3" 1911, if you look closely you can see the Colt "Ponies" on the slide before and after the words "Colt Defender") , It is clearly too small to be an Officers ACP or a Kimber as it was previously listed.
I wholeheartedly doubt that's a Mustang. It's got Novak sights, a full sized slide stop, a match trigger, and a beavertail on the backstrap. Not to mention the barrel diameter looks to be too large for .380 ACP ammo. It made more sense as an Officer than a painted plastic Mustang. (FYI the plastic gun doesn't match his either.)
Well it is too short to be an Officers ACP but I agree, it isn't a Pocketlite.
Ruger Blackhawk
When Hartigan (Bruce Willis) returns from being in prison for eight years, and meets up with the now nineteen year old Nancy Callahan (Jessica Alba), she gives him a stainless steel Ruger Blackhawk which he uses to shoot Roark Jr. a.k.a. Yellow Bastard (Nick Stahl) in the throat, and to kill a cop while going to rescue Nancy at the Roark family Farm. Nancy herself wears a pair of golden Ruger Blackhawks and some old town prostitutes are seen with them, noticabley the black masked Prostitute and Dallas (Patricia Vonne).
Colt Detective Special
In the beginning of the film, Detective Hartigan (Bruce Willis) packs a Colt Detective Special in an ankle holster as his "Spare Rod". He attempts to use it when he is shot several times by his partner, Bob (Michael Madsen), but is only shot again when he attempts to pull it out.
Walther P22
The first Walther P22 we see is in the hand of an Old Town prostitute, which is tutone with a compensator [Called the P22T or Target]. The next one we see is the one that Hartigan (Bruce Willis) takes from Shlubb (Nick Offerman) which is also tutone and is seen being affixed with a suppressor by Shlubb when going to pick up Hartigan. Hartigan's Walther P22 is notably seen while it's on the the seat of the stolen Ferrari next to Klump's (Rick Gomez) Beretta M93R Auto 9.
Smith & Wesson Model 19
Manute's henchman Stuka (Nickey Katt) packs a Smith & Wesson Model 19 with rubber grips. Manute (Michael Clark Duncan) himself appears to use the same revolver in the alley before being shot several times. He then flees from the alley and is stopped by Miho (Devon Aoki), where he is seen using two Model 19s, before she cuts him in half with a large blade spear type weapon.
Colt Officers ACP M1991A1 Series 80
In the beginning of the movie, Roark Jr. (Nick Stahl) carries a Colt Officers ACP with a blued frame and stainless steel slide, which he uses to shoot Detective Hartigan (Bruce Willis) several times non-fatally and hold Nancy Callahan (Makenzie Vega) hostage but loses it when Hartigan blows his arm off on the dock.
Smith and Wesson Model 60
Wendy (Jamie King) packs a Smith & Wesson Model 60 in .357 Magnum throughout the film, firing it several times at Marv (Mickey Rourke), and nearly kills Kevin (Elijah Wood) with it, before Marv knocks her out. - I actually think it is a Taurus revolver by the barrel and the insignia on the side.
Mk. 2 hand grenade
A grenade similair to a Mk. 2 hand grenade (likely just a plastic molded prop made to resemble the one in the comic book) is used by the bomber to send Dwight flying into the tar pits and to send Miho airborne, but not kill her.