Beethoven

The following guns were used in the film Beethoven:.

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Beethoven (1992)

Unknown Revolver

Dr. Herman Varnick (Dean Jones) is paid by a shifty-looking businessman to use large dogs with big skulls to test an experimental, explosive-tipped ammunition. Naturally he chooses the Newton family's titular pet, Beethoven the friendly St. Bernard, to be his test subject.

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The revolver in its carrying case on Varnick's desk.

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Varnick examines one of the bullets.

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Dr. Herman Varnick (Dean Jones) prepares to shoot Beethoven during the film's climax (fear not, dog lovers, Charles Grodin saves the day). Note that this revolver has an external ejector rod, whereas the Colt Python, as previously (mis)identified, has an internal rod and a full-barrel underlug.

Look's to me like a Smith & Wesson Model 65 in .357 Magnum with 4 inch barrel and Houge grips. (Explosive tipped ammo for a dog? That's a bit morbid for a kids movie)