Ty Curtis (Omari Hardwick) keeps a nickel plated Colt Government Model pistol in a safe box, alongside a Beretta 92FS. He takes it out and uses it in the pilot episode after Lt. Shaw (Dylan McDermott) sends him back undercover.
Beretta 92FS
Ty Curtis has a Beretta 92FS in a safe box alongside his M1911 in the pilot episode. The Beretta 92FS is also used by a guard and one of Warren Volk's men in the bank during the pilot episode. Dean Bendis (Logan Marshall-Green) also has a Beretta 92FS in a locked box along with his drugs and cash hidden under his floor boards.
Robert Franzine (James Russo) carries as his sidearm in the pilot episode a Ruger KP90. He uses it most notably in the bank "robbery" during the pilot episode.
Ruger KP89
Johnny Moosa (Gonzalo Menendez) carries a Ruger KP89 as his sidearm in the second episode. He uses it to threaten Ty.
Glock 17
Jaimie Allen (Nicki Aycox) carries a two-tone Glock 17 as her sidearm only in the pilot, and can be seen using it in the gun range, and also during the climax shootout of the pilot. Her Glock switches into a Kahr 9 after the pilot, and remains her sidearm for the rest of the series.
Kahr 9
After the pilot, Jaimie Allen Nicki Aycox carries a Kahr 9 9mm pistol as her sidearm.
Carter Shaw (Dylan McDermott) uses a SIG-Sauer P228 as his sidearm throught the first half of the series. He then switches to a customized Colt MK IV Series 80.
In episode 2 ("Guns, Strippers and Wives"), Jimmy Boyd (Gregg Henry) is briefly seen putting a Smith & Wesson 4506 to the head of Ty. This is the same handgun used by Keanu Reeves in the 2008 film Street Kings. A pair of snake eyes dice with "Vice Special" is printed on the right side of the slide between the ejection port and the muzzle.
A drug buyer tries to pull a Smith & Wesson Model 640 Centennial on Shaw in the second episode, when they are trying to come up with a 100 grand to save Ty.
Smith & Wesson Model 36
A Smith & Wesson Model 36 snub-nose revolver can be seen Reuben Pike's trunk in the third episode, Purity. Bendis and Allen plant this gun, and some coke, in Pike's trunk to make sure he will be co-operative.
Unknown snub-nosed revolver
In the pilot episode, one of Warren Volk's bodyguards has an unknown snub-nosed revolver in an ankle holster. He tries to use it but is gunned down by one of Franzine's crew members.
Sub-machine guns
Heckler & Koch MP5A2
In the second episode when Ty is undercover he is trying to buy guns from Johnny Moosa. Among other weapons there are Heckler & Koch MP5A2s. Moosa also tests one of the MP5's, which is fitted with a holographic sight. A thug from Moosa's crew also tries to use an MP5A2 during the trade in episode 2, but Dean intervenes.
Rifles
M4A1
Most of Robert Franzine's (James Russo) men use M4A1 carbines in the pilot episode, including Dean Bendis. They most notably use them during the bank job, and the ensuing shootout. A couple of M4A1s are also seen in episode 2. First in the container when Ty checks Moosa's merchandise, and later in the back of a van during the trade off.
Dragunov SVD
One of the weapons that Carter used to stage a fake weapon transportation deal in the second to last episode.
Shotguns
Remington 870
Lieutenant Carter Shaw (Dylan McDermott) uses a Remington 870 shotgun with synthetic furniture, rear pistol grip and extended barrel in the pilot episode. One of Robert Franzine's (James Russo) men is seen loading a Remington 870 when they prepare for the bank job. In the 3rd episode "Purity", Dean uses one to bust a drug deal.
Benelli M1 Series Super 90
A Benelli M1 Super 90 was used by one of the "Winters Bros." in the episode O.I.S. during the raid on the drug lab.