As in the previous film, RoboCop (Peter Weller) carries the Beretta 93R "Auto 9" as his sidearm of choice. Moreover, he is actually seen reloading the weapon on a few occasions (something he never seemed to do in the first film).
Officer Anne Lewis (Nancy Allen) carries a SIG-Sauer P228 as her sidearm throughout the movie, which was a brand-new pistol at the time that RoboCop 2 was made (this is, in all likelihood, the first film ever to feature this gun, because the P228 was first introduced in 1990, the same year this film was made). The P228 can also be seen in the hands of the Little League coach-turned-robber during the incident at the electronics store.
Hob (Gabriel Damon) carries a UC-M21 as his weapon-of-choice throughout the film. This gun was designed by Dave Boatman and based on an earlier version conceived by Eugene Stoner, the Ares FMG. Stoner developed it in the early 1980s as a PDW for high-ranking politicians and wealthy businessmen in kidnapping prone nations. The blue exterior gives the gun the appearance of a plastic lunchbox, in order to fool unsuspecting cops who don't realize that Hob is a young drug lord.
There are several appearances of the Desert Eagle Mark I in the film. The first is during the gun store robbery in the opening, when a drug dealer steals a blued .357 Magnum version and uses it to kill the store owner. The second appearance is in the hands of Hob (Gabriel Damon), who uses a nickel .44 Magnum model to shoot RoboCop in the visor after RoboCop's directives prevent him from shooting a kid, a fact Hob torments him on.
During the gun store robbery in the beginning, the robbers can be seen taking Pauza P50 long-range sniper rifles from a display case which is specifically marked "Pauza Specialties". RoboCop himself later uses a Pauza P50, representing the 'Cobra Assualt Cannon' from the previous film, when he confronts RoboCop 2 (AKA RoboCain) at the OCP Civic Centrum.
- Robert Pauza designed and built the Pauza P50. It is a .50 Caliber semi-auto rifle with a tilting bolt action based on the Tokarev.
An unmodified Beretta 93R (not the Auto 9) is used by one of Hob's thugs during the meeting with the mayor. Another can be seen in the gun store at the beginning of the film.
During the gun store robbery scene, a drug dealer named Chet (played by Thomas Rosales Jr., who always plays characters in movies who get killed) fires at RoboCop's crusier with an M136 AT4 rocket launcher.
Norinco Type 56 AK rifles are a very common weapon used in the film by Cain's (Tom Noonan's) thugs. Nearly every variation of the Type 56 appears in the film, including the fixed stock Type 56, the under-folding stock Type 56-1, and the side-folding Type 56-2. The Type 56 rifles in the film all seem to have some type of unusual flash hider which looks similar to that of the AK-74, and some of the rifles also have Bakelite magazines.
The Heckler & Koch MP5K is another weapon used by Cain's thugs. In one scene, RoboCop kills a drug dealer who is using his MP5K to hold a baby hostage.
Many of the Detroit Police Officers in the film are seen using M16A2 assault rifles fitted with MWC "90-rounder" inverted drums, though at least a few have 30-round translucent magazines. Like most of the Hollywood "M16A2s", these all have M16A1-style flash hiders (as evidenced by the "starburst" pattern muzzle flash whenever they're fired).
Some of the Detroit Police Officers use the Korean-made Daewoo K1A1 carbine. Like their M16A2s, these are also fitted with 90-round inverted drum magazines. All of them also seem to have M16-style flash hiders rather than the long, conical flash hider that is more commonly seen on the K1A1.
Anne Lewis can be seen using a pistol-grip Benelli M3 Super 90 shotgun in the climax when the cops are shooting at RoboCop 2. Several other officers use these shotguns as well.
Angie (Galyn Görg) can be seen using a pistol-grip, sawed-off Remington 870 fitted with a grenade launcher during the shootout at the Nuke plant. A folding-stock Remington 870 shotgun is briefly visible in the hands of a Detroit police officer in the climax.
The M134 minigun is the main weapon of "RoboCop 2" or "RoboCain", the law enforcement droid that Cain's brain is implanted in. The minigun is seen being fired when RoboCop 2 bursts in on the drug deal as well as when the robodroid is introduced to the public.
