Manhunter is the 1986 thriller directed by Michael Mann and was the first theatrical adaptation of the Thomas Harris novel Red Dragon. This film featured the first appearance of Hannibal Lecter (named Hannibal Lecktor here), here portrayed by Brian Cox. The book was later adapted again with Anthony Hopkins as Lecter in 2002's Red Dragon.
The following weapons were used in the film Manhunter:
FBI Special Agent Will Graham (William Petersen) carries a Charter Arms .44 Special Bulldog when he's uses as bait to capture the "Tooth Fairy". He's given Glaser Safety Slugs for the Bulldog for a "guaranteed one-shot stop". He pulls the Bulldog during the sting operation as well in the final confrontation with Francis Dollarhyde (Tom Noonan).
Remington 870
A Remington 870 is used by serial killer Francis Dollarhyde (Tom Noonan) with a sawed-off buttstock to shoot up his house at the end of the film. He kills 2 cops, wounds Jack Crawford (Dennis Farina) and attempts to kill Graham (William Petersen) before he pumps 6 rounds into him with his Bulldog (though before Dollarhyde was also wounded by another cop's bullet). The 870 used in the film was the personal shotgun of the films weapons expert Jim Zubiena. It was teflon coated, extended mag, muzzle brake, Pachmayr pistol griped unit.
Colt Commando
Used by cops at the middle and the end of the film.
Used by Francis Dollarhyde (Tom Noonan) to shot 3 times and kill Ralph Dandridge (Ralph Mandy in original novel), played by Bill Cwikowski).
The pistol is covered by something in most of the shots, so it's very difficult to say even what was used in this scene - pistol, or an unknown special effects device. Though, pistol anyway supressed (that's easy to know cause of it's sounds and facts listed about Dollarhide in the movie and in the novel)