According to the computer readout seen during Season 1, Airwolf's offensive weapons include 40mm Cannons and .50 caliber Chain Guns mounted on each side in addition to its rocket pods. The machine guns were shown to have telescoping barrels, which allowed them to be stowed away when the helicopter configured itself to fly supersonic.
The M1911A1 is primarily carried by Dominic Santini (Ernest Borgnine) in the series. Caitlin O’Shannessy (Jean Bruce Scott) uses the M1911A1 in Season 3's premiere "The Horn of Plenty" (S3E01).
The Walther PPK is carried by various characters throughout the series.
Assault Rifles
M16A1 (A2 handguards)
The M16A1 with A2 handguards is used in "Horn of Plenty" (S3E01).
Ruger AC556K
The Ruger AC556K is another weapon used throughout the series.
Submachine Guns
Uzi
A full size Uzi is used throughout the series, sometimes fitted with a suppressor.
Micro Uzi
A Micro Uzi is used by Archangel (Alex Cord) in "Birds of Paradise" (S3E22).
Heckler & Koch HK94 (Chopped & Converted)
The "Fake MP5", the Heckler & Koch HK94 converted to full auto fire and with a shortened barrel is used in the series. This version was used in many films and television series during the 1980s and 1990s.
The MAC-11 is used notably by Hawke in the pilot episode.
Machine Guns
M60
The M60 is seen mounted on jeeps in Season 3's premiere "Horn of Plenty" (S3E01).
Other
FIM-43 Redeye
In "Day of Jeopardy" (S3E15), Hawke is seen using an FIM-43 Redeye launcher to take out two fighter jets. The launcher is held the wrong way when it is seen used.