In some scenes, Agent 86's SIG P226 changes into a SIG-Sauer P228 pistol instead.
AKMS
An AKMS is seen in the hands of an Afghani guard making rude remarks about women as they pass, one of which is the wife of the man next to him. Another is seen in the hands of a guard in the nuclear weapons factory hidden inside the bakery.
Skorpion SA Vz 61
When Maxwell Smart/Agent 86 (Steve Carell) and Agent 99 (Anne Hathaway) infiltrate Ladislas Krstic's (David S. Lee) mansion, one of his guards holds a Skorpion SA Vz 61 on him before he is rather awkwardly dissarmed by 86. When the Skorpion gets knocked out of 86's hands, 99 kicks it up to him just in time to kill Krstic before he kills them.
AKS-74U
Krstic (David S. Lee) is seen using an AKS-74U when he tries to kill Agent 86 and Agent 99, before 86 kills him.
The Desert Eagle is the weapon of choice for Agent 23 (Dwayne Johnson). His model is the .44 Magnum Israeli model without a notch on the barrel and without a hooked safety.
Beretta M92F
A Beretta 92 is taken from the CONTROL display case by Agent 86 and also appears in the hands of Bruce (Masi Oka).
Agent 99 (Anne Hathaway) packs a Sig Sauer P232 throughout the film and also on the film's promotional posters. The Sig Sauer P232 is the stainless version of the popular P230.