A CIA operative, named Vargas(Fares Fares), uses a SIG-Sauer P226 as his sidearm throughout the film. He wields it several times in the film, sometimes fitted with a suppressor. Several of Vargas' henchmen also use P226s as their sidearms.
Tokarev TT-33
An assassin uses a Tokarev TT-33 near the beginning of the film, when he searches for Tobin Frost.
Steyr M9A1
Tobin Frost (Denzel Washington) uses a Steyr M9A1 as his sidearm in Cape Town, but dumps it before entering an American embassy.
Vektor Z88
South African Police Service (SAPS) officers use Vektor Z88 handguns as their sidearms in the film, most notably seen during the shootout at Green Point Stadium. Frost takes one from a dead officer, and uses it for a majority of the film.
Glock 17
Agent Miller (Jake McLaughlin) uses a Glock 17 as his sidearm during the attack on the safehouse. David Barlow (Brendan Gleeson) also uses a Glock in a later scene.
Several of Vargas' hitmen are armed with Heckler & Koch UMP9 submachine guns.
IMI Uzi
A hitman uses a suppressed IMI Uzi during a car chase and later during a raid.
Rifles
Olympic Arms K23B
Vargas (Fares Fares) uses a short-barreled AR-15 derivative, similar to a Olympic Arms K23B during several attempts to kill Frost. The rifle is initially equipped with a telescopic sight and suppressor, but is mostly seen with an EOTech holosight.
Colt M4A1 Carbine
Members of the CIA extraction team led by Daniel Kiefer (Robert Patrick) wield M4A1 Carbines when the safe house is attacked.
AK-47
Several hitmen use AK-47s during the safe house attack and later during a gunfight in a shantytown.
Vektor R6
Carlos Villar (Rubén Blades), a forger and friend of Frost's, uses a Vektor R6 carbine while defending his home from an attack.
Machine Guns
M249 Paratrooper
A hitman who breaches the door of the safe house fires a M249 SAW Paratrooper before being cut down by one of the CIA agents.