The SIG-Sauer P226, with accessory rails is the sidearm of U.S. Deputy Marshals Charlie Duchamp (Laz Alonso) and Ray Zancanelli (Domenick Lombardozzi). Several criminals also use the P226.
Glock 17
The Glock 17 appears as the sidearm of various law enforcement personnel. One is also used by Damien Fontleroy to kill Charlie Duchamp in "An Unjust Death".
In "Fun with Chemistry (S1E7) Charlie hands Erica his backup gun, a Glock 26, when they clear a building.
M1911A1
In "Round Two" (S2E2), Brody Ardell (James Harvey Ward), an undercover FBI agent, is given an M1911A1 by the Victor Mannion (Channon Roe), a fellow escape .
In the Season 1 Pilot eppisode, and again in "Fun with Chemistry" (S1E7), the escaped convicts can be seen using a Smith & Wesson Model 686 with a 3-inch barrel.
Shotguns
Remington 870
In the season 1 episode 5, Queen of Hearts, Deputy US Marshal Ray Zancanelli is seen with a Remington 870 shotgun with synthetic furniture.
Ithaca 37
In the episode "An Unjust Death", a man meets Damien Fontleroy at the door of his house armed with an Ithaca 37 shotgun, though Damien talks him into setting the weapon aside. When the man lets Damien into his home to use the phone, Damien grabs the shotgun and pistol-whips him in the head with it before shooting him.
Mossberg 590
In the episode "An Unjust Death", a prison guard can be seen armed with a Mossberg 590 shotgun with a high-capacity magazine tube when Damien Fontleroy breaks out of prison.
Rifles
Ruger Mini-14
In "Like Father, Like Son" (S1E6) Christian Beaumont (Zack Ward), an anti-government extremist, opens fire on the Breakout Kings with a Ruger Mini-14 when they raid his bunker.
AR-15 A2 HBAR
In the episode "An Unjust Death", another prison guard can be seen carrying an AR-15 A2 HBAR when responding to Damien Fontleroy's jailbreak.
M16A4 Rifle
An M16A4 rifle is seen in the season 1 episode 7 Fun with Chemistry by a corrections officer (Ted Hallet).
Other
DefTech 37mm launcher
A prison guard in "One for the Money" (S1E9) uses a DefTech 37mm launcher to fire a tear gas round during a riot.