San Diego Police Department Detective Michael Dooley (James Belushi) carries a Beretta 92SB with wood grips as his primary weapon in this movie. The handgun is most prominently seen when Dooley lays his gun on the hospital tray table. In one scene, he mentions to "Jerry Lee", his new German Shepherd partner, that he's going to pull out his "revolver". (How do you mistake a Beretta 9mm for a revolver?!!)
Beretta 92F
A Beretta 92FS is briefly seen drawn by San Diego Police during the standoff.
M60
When a helicopter shoots and blows up Dooley's car, an M60 can be seen firing at the car.
Smith & Wesson Model 5906
Lyman (Kevin Tighe) uses a 9mm Smith & Wesson 5906 in stainless steel. He uses it first to hold Dooley's wife, Tracie (Mel Harris) at gunpoint, and again to shoot Jerry Lee (the dog in the film). When Dooley says the line "You think this is a Nine Millimeter mistake?", he wasn't kidding. People have said that it is really a 4506, but close examination of freeze frames reveal it's a 9mm 5906.
Smith & Wesson Model 14
Throughout the film, uniformed officers of the San Diego PD can be seen wearing and aiming Smith & Wesson Model 14 revolvers. Contradictions state that the guns are really Model 27s, but examination of the barrel reveals it is really a .38 Model 14.
Smith & Wesson Model 19
Lieutenant Byers carries a 4-inch Smith & Wesson Model 19 in his hip holster. It is never seen out of it's holster.