Blade's (Kirk "Sticky Fingaz" Jones) Customized H&K USP Matches from the previous Blade films carry on to the series. Shen (Nelson Lee) can be seen wielding one anytime he requires a weapon, Vanessa (Sonja Bennett) and a vampire in the Paris tunnels can be seen with one after he pulls it from Blade's thigh holster.
Walther P99
Marcus Van Sciver (Neil Jackson) uses a Walther P99 to shoot Zack Starr (David Kopp) in the beginning of the series.
Beretta 92FS
Krista Starr (Jill Wagner) uses a Beretta 92FS throughout the pilot.
Glock 17
Detective Brian Boone (Bill Mondy), FBI Special Agent Ray Collins (Larry Poindexter), and Detective Donny Flannigan (Peter Hall) carry Glock 17's as their service weapons. Collins interestingly carries a second Glock 17 as his backup weapon. Krista carries two while operating in France with a Chthon hit team. And several unnamed vampires and familiars can be seen with them as well.
Calico M950
Blade utilizes a Calico M950 pistol in the series, which in the series is actually a shotgun. It's also handled by Krista, and used by Agent Collins.
Colt Detective Special
Used by a thug in a flashback to Blade's childhood in episode 8, Sacrifice.
Submachine Guns
Heckler & Koch MP5A3
House of Chthon Guards, Red Teams, and Van Sciver's security team are armed with Heckler & Koch MP5A3's. Both Krista and Chase (Jessica Gower) use them while operating with Red Teams. Blade also commandeers one during the pilot episode.
Heckler & Koch MP5K
Used by Krista when raiding the Armaya funeral home in episode 6, The Evil Within.
SA Vz.61 Skorpion
Used by Vladya (Mike Dopud), unnamed members of the House of Armaya, and Boone during episode 6, The Evil Within.
FN P90
Used by a member of the Chthon hit team in episode 7, Delivery.
IMI Uzi
Full sized Uzi's are used by two members of the hit team in episode 7, Delivery.
Intratec TEC-9
Used by the lead member of the hit team in episode 7, Delivery.
MAC-11
Used by one of Cain's guards in episode 3, Death Goes On.
Rifles
Heckler & Koch SL8
Krista Starr attempts to kill Marcus Van Sciver with a suppressed Heckler & Koch SL8 in the pilot episode.
Used by Shen with silver bullets to try and kill members of the Bad Bloods vampire gang in episode 4, Bloodlines.
Shotguns
Krieghoff Model L
The Modified Krieghoff Model L reappears from Blade: Trinity as one of Blade's weapons. It's seen being used by Krista, and a Abraham Whistler (Adrian McMorran) during a flashback to 1977.
Franchi SPAS-12
Seen being held by one of Cain's crew in episode 3, Death Goes On.
SWD/Cobray Street Sweeper
Seen being held by one of Cain's crew in episode 3, Death Goes On.