Trinity (Carrie-Anne Moss) opens the film by diving out of a high-rise office building's window while wielding two IMI Micro Uzis, firing them at a pursuing Agent. She also closes the movie when the dream Neo (Keanu Reeves) has comes true.
Beretta 92FS Compact
Trinity (Carrie-Anne Moss) carries a pair of Beretta 92FS Compact pistols as her sidearms in the film. She draws one and aims at Persephone (Monica Bellucci) when she desires to kiss Neo (Keanu Reeves). She later pulls one of them and fires it into one Twin's arm when he blocks open a door leading to a parking garage.
IMI Desert Eagle Mark XIX
As per the norm in the Matrix series, the Agents in the film can be seen wielding IMI Desert Eagle Mark XIX pistols in .50 AE. Smith (Hugo Weaving) uses them to terrifying effect when a group of his clones, all carrying identical Desert Eagles, volley fire them at the protagonists as they're trying to flee, fatally wounding the Keymaker (Randall Duk Kim) with multiple hits to the torso. Unlike the first film, the Desert Eagles in this film have a polished finish instead of the original Matte black.
Heckler & Koch UMP-45
During the freeway chase scene, one of the Twins opens fire on the protagonists with a Heckler & Koch UMP-45 fitted with a C-More red dot sight and an almost bottomless magazine. Showing no concern for innocents caught in the crossfire, he opens fire on a luckless Chevy Tahoe SUV that winds up between him and his target, causing it to flip and trigger a spectacular chain-reaction pileup.
Glock 18C
Morpheus (Laurence Fishburne) uses a Glock 18C in the confrontation with the Twins in the parking garage, then in the following freeway chase scene, where he uses it to destroy the Twins' Cadillac Escalade after using a katana to help flip the vehicle. Morpheus's Glock 18C is fitted with a 19-round magazine during the scene in the parking garage, then reloaded with a 33-round extended magazine during the freeway chase.
Walther P99
While making their way through the hallway of doors, the protagonists have an unexpected encounter with Agent Smith (Hugo Weaving). When he tells them that he "wants everything", Morpheus pulls out a Walther P99 and holds it to his head, asking if "everything" included a bullet from the gun. Before Morpheus can fire, a swarm of Smith clones burst in and overpower them.
COP 357 Derringer
After agreeing to help the protagonists, Persephone (Monica Bellucci) kills one of her husband's henchmen and threatens another with a COP 357 Derringer with pearl grips, loaded with silver bullets.
Stevens 67 (Sawed-off)
During the meeting where the machines' plan to attack Zion is revealed, one of the Zion rebels guarding the door is seen carrying a nickel Stevens 67 shotgun with a sawed-off barrel, black pistol grip and foregrip.
SIG-Sauer P229 Sport
Ghost (Anthony Brandon Wong) packs a stainless steel SIG-Sauer P229 Sport. He is briefly seen loading it just before the car he and Niobe (Jada Pinkett Smith) are in is rear-ended by a semi truck whose driver has changed into an Agent.