A suppressed version of a Heckler & Koch UMP-9 is carried by James Bond on the teaser poster. It's chambered for the 9x19mm (as indicated by the curved "banana" style magazine.) James Bond (Daniel Craig) uses the UMP (this time unsuppressed) during the pre-titles car chase to dispatch the last of Mr. White's gunmen and evade capture. Presumably, this is the same weapon Bond uses to wound Mr. White at the end of Casino Royale.
Heckler & Koch G36C
The gunner in the first Alfa Romeo sedan during the pre-title Aston Martin chase uses a Heckler & Koch G36C assault rifle, scoring several ineffective hits on Bond's DBS and a more damaging shot on a box truck's tires. Many of Greene's henchman can be seen with a G36C during the boat chase scene.
FN Minimi Paratrooper
An FN Minimi (Paratrooper model with retractable stock) is used by the gunner in the second Alfa Romeo chasing Bond in Siena, Italy. He also uses it to dispatch a Carabinieri SUV that took up pursuit behind them.
Beretta 92SB
The Carabineri officer who fires at the Alfa Romeo in the car chase scene with a Beretta 92SB. The corrupt Bolivian police officers hired by Dominic Greene draw Beretta 92SB pistols when they pull over Bond and Camille's Range Rover and discover a beaten Rene Mathis in the back of the truck.
SIG-Sauer P226
Mr. White's sleeper agent, Henry Mitchell (Glenn Foster), uses a SIG-Sauer P226 as his sidearm. He draws it while in Siena to shoot one of M's bodyguards and then fires on Bond and M before running off. He uses this gun for the duration of the Siena chase scene. Later in the movie, Bond is seen taking a P226 from another agent during an escape from his arrest in the hotel lift in Bolivia. He then uses it to raid the Perla de las Dunas, ultimately losing the weapon when Dominic Greene attacks him as the hotel burns.
Walther PPK
Bond's main sidearm throughout the film is a Walther PPK, which he uses until he loses it in the freefall scene after his plane crashes. He is then seen using the PPK again to threaten Vesper's boyfriend Yusuf at the film's conclusion.
Smith & Wesson M&P 360
Bond discovers a Smith & Wesson M&P 360 when he opens Edmund Slate's briefcase in front of Camille.
Rohrbaugh R9s Stealth
The pistol that Camille (Olga Kurylenko) uses appears to be a Rohrbaugh R9s Stealth (the 'S' model indicates that it is the version with sights, the black finish on the slide means that it is the 'Stealth' edition). She first draws it on Bond (Daniel Craig) when he discovers that the man he was impersonating was sent to kill her, firing a shot that misses him, but forces him out of her car. She then uses it during the hotel shootout.
IMI Uzi
Dock guards in Haiti carry the Uzi submachine gun. This is a original full size model, judging by the stock and handgrips, although curiously the Uzi that the gate guard is carrying lacks the folding stock.
Heckler & Koch MP5K-PDW
General Medrano's men carry Heckler & Koch MP5K-PDWs during the boat chase. CIA officers are also seen using suppressed versions. The stocks of these MP5K's appear to be UMP-style instead of the PDW folding stock.
SIG SG 542
During the boat chase in Haiti, one of General Medrano's men uses a SIG SG 542 assault rifle. When Bond smashes into their boat with his own, the gunner is seen either clearing a jam or attempting to reload the rifle and is unable to get it operational again before Bond makes a second pass and destroys the boat's outboard engine.
The Glock 17 are used by Greene's bodyguards as they pursue Bond during the Tosca performance. Two of his henchmen also fire at Bond with Glocks at the Perla De Las Dunas hotel.
SIG P210
Bond acquires a SIG P210 with gold inlayed engraving (Gun is actually a special of the Sig 210 commemorating the 50 years of P49 in the Swiss army (1949-1999)limited to only 500 being made, The first series which goes until N° 250 is manufactured according to the same principle as 210-1 A i.e. without notch of stop to the hammer flat stop of breech and round safety. The second series of N° 251 to 500 like the 210-2A.) from General Medrano's room when he tries to rescue Camille. Seeing that Camille is paralyzed with fear from the fire that has engulfed the room, Bond prepares to kill Camille with it to put her out of her misery, but then uses it to aid their escape when Bond sees a hydrogen fuel cell that he blows up to create a route out.