When Tommy Five-Tone (Danny Aiello) shows up in Rome to tell Eddie, a.k.a. the Hudson Hawk (Bruce Willies) that he has betrayed him, he takes out a Browning Hi-Power. Tommy and Eddie fight over the gun and Eddie ultimately shoots Tommy with it, only to discover it was loaded with blanks, part of a ruse to fool the Mayflowers.
IMI Uzi
The Uzi is used by the Mayflowers' purple-uniformed guards at Castle Da Vinci. CIA operative "Butterfinger" (Andrew Bryniarski) also uses one.
When the Mario Brothers kidnap Eddie in an ambulance, Antony Mario (Carmine Zozzora) points an M1911 pistol at him. A struggle ensues which results in the gun winding up in the hands of Antony's brother, Cesar Mario (Frank Stallone).
Beretta Model 70
The guards at the Vatican use Beretta Model 70's as their sidearms. One fitted with a suppressor is used by Darwin Mayflower (Richard E. Grant).
Beretta 3021 Tomcat
After the Mayflowers' henchmen, the identical twins "Igg" and "Ook," perform badly, Darwin jokingly suggests killing them. Minerva Mayflower (Sandra Bernhard), however, thinks he's being serious.
Fictional grenade/rocket launcher
A manufactured Rocket Launcher is used by Hudson Hawk (Bruce Willis)and Tommy (Danny Aiello) at the film's climax.