2nd Generation Glock 22 pistols appears in the film as the main weapon of U.S. Deputy Marshal Sam Gerard (Tommy Lee Jones) and his fellow Deputies. Later in the film, U.S. Diplomatic Security Service Special Agent John Royce (Robert Downey Jr.) can be seen using one when he and Gerard are pursuing Mark Sheridan (Wesley Snipes) aboard the cargo ship, breaking up a fight between Sheridan and Gerard by shooting Sheridan in the shoulder after Sheridan gets ahold of Gerard's Glock and pistol-whips Gerard in the back with it. Near the end of the film, Royce attempts to use his Glock to kill Sheridan and Gerard, only to discover that Gerard had replaced the magazine with an empty one from his gun. It is revealed in the film that Gerard carries the Glock 22 during the hospital scene, when Gerard points out that Royce is now carrying a Glock and Royce replies, "Yeah, Glock .40, just like yours."
When Royce and Gerard first meet, Gerard asks to see what kind of gun Royce is carrying. Royce then produces a stainless steel Taurus PT945 which Gerard calls a "nickel-plated sissy pistol", advising Royce to get a Glock instead. During the manhunt in the swamp, Sheridan takes the pistol from Royce and holds him at gunpoint in a short standoff with Gerard before shooting Gerard in his bulletproof vest in order to make his escape. Royce manages to retake the weapon and later uses the pistol to fatally wound Deputy Marshal Noah Newman (Tom Wood) when Newman catches Royce about to kill Sheridan in cold blood at the Lorelei Building. Royce then tries to pass it off as the gun Sheridan used to kill Newman with the serial number filed off, but Gerard recognizes it from their earlier meeting.
When boarding the prisoner transport flight, Gerard removes both his Glock 22 and a sub-compact Glock variant that he carries in an ankle holster as a backup weapon. This is most likely a Glock 27, which is chambered for the same .40 Smith & Wesson cartridge as his Glock 22. After this scene, the baby Glock is not seen for the rest of the film, likely lost in the crash-landing incident.
During the cemetery scene, Sheridan and the Deputies come under fire by U.N. Cultural Attache of China Xian Chen (Michael Paul Chan) wielding a Colt Sporter II Carbine fitted with a scope and sound suppressor from the roof of the funeral home. He only manages to kill U.S. Diplomatic Security Service Special Agent Frank Barrows (Rick Snyder), being arrested by Deputy Marshals Bobby Biggs (Daniel Roebuck) and Savannah Cooper (LaTanya Richardson) before he can score any more hits.
Following the car crash in Chicago, firefighters responding to the accident find a blue steel Kahr K9 hidden in the glovebox of Sheridan's tow truck (although the gun is mostly covered up by the holster it's in, you can see "K9" on the end of the slide). The discovery of this weapon leads to Sheridan being arrested on concealed weapons charges.
When Sheridan (Wesley Snipes) hijacks a semi truck belonging to a man named Earl (Ray Toler), he also takes possession of the driver's Ruger SP-101 revolver and some extra ammo for it. He later uses it during the manhunt in the swamp, holding Royce at gunpoint with it.
While on board the prisoner transport flight, a prisoner retrieves an XL-17 pen gun hidden in a roll of toilet paper in the lavatory. The prisoner then attempts to use the weapon to kill Sheridan but fails, the shot shattering a window of the plane and causing an explosive decompression that sucks the would-be assassin and several other prisoners and guards out of the plane and forces an emergency landing. Of course, a single bullet hole cannot cause explosive decompression in real life nor could a .22 round pierce the window at all.
Upon reaching New York City, Sheridan (Wesley Snipes) meets with an old friend he calls "Sarge" (Lorenzo Clemons) who provides him with materials needed in his mission to exonerate himself, including a stainless steel Colt Gold Cup National Match Series 80. He then uses it when he confronts Agent Barrows (Rick Snyder) in the cemetery, pistol-whipping him in the face and holding him at gunpoint with it. He then uses it in the ensuing shootout with Xian Chen (Michael Paul Chan), and while being pursued to the Lorelei Building by Gerard (Tommy Lee Jones) and company. Interestingly, Gerard can be seen holding this pistol in promotional material for the film, but never uses one on-screen.
Remington 870 shotguns make several appearances in the film, first in the hands of prisoner transport flight guards following the crash-landing, then in the hands of locals helping with the swamp manhunt.
A Maveric 88 "Persuader", a pistol gripped, inexpensive version of the Mossberg 500 is recovered by Gerard (Tommy Lee Jones) from a baby's crib during the fugitive arrest in the beginning of the film. One of the suspects tries to get this weapon so that he can shoot Deputy Marshal Noah Newman (Tom Wood), but Newman shoots him with his Glock 22 in the shoulder before he can do this. Gerard later takes this weapon and uses it to intimidate another suspect. It is noted as a Maverick 88 by its safety moved from the reciever tang to the trigger guard.
During the swamp scene, a Kentucky State Police officer in a helicopter can briefly be seen with a Heckler & Koch SR9(T) sniper rifle, loaded with a 20-round magazine.
When Royce (Robert Downey Jr.) finds his Glock 22 has been emptied on him, he makes a last ditch effort to kill Gerard (Tommy Lee Jones) by drawing a nickel plated Smith & Wesson Model 36 before being gunned down. It does not appear to be the Ruger SP-101 from earlier in the film as previously mentioned.
When Sheridan (Wesley Snipes) is found in the swamps, Gerard (Tommy Lee Jones) and a local boatman fire flare guns into the air to mark their positions.
