FBI agent Bob Sweet (Ned Beatty), posing as a vitamin salesman on the Silver Streak, carries a first generation Colt Detective Special in a waist holster. He gives it to George Caldwell (Gene Wilder), but Caldwell drops it while climbing outside the baggage car. Caldwell later grabs the Detective Special that the villian, art dealer Roger Devereau (Patrick McGoohan), keeps in his holster. After Caldwell fires all six shots during the baggage car shootout (causing the trigger to continuously "click" empty), Grover Muldoon mocks him, asking if he thought he was in a Western. Chief Donaldson (Len Birman) carries a Detective Special as well, firing it at the junction shootout with Devereau's men.
Devereau's henchman Reese (Richard Kiel) uses a Smith & Wesson Model 19 to kill Sweet and then attempts to use it to kill Caldwell. For some reason, the shots from the Model 19 were made to sound as though they came from a suppressed pistol even though the weapon seen in the film has no suppressor.
George Caldwell (Gene Wilder) grabs a "spear gun" when he drops his Detective Special during the fight with Reese. He shoots him on top of the train with it.
Sheriff Oliver Chauncey (Clifton James) carries a Colt New Service as his sidearm, which George Caldwell (Gene Wilder) takes from him and uses. Grover T. Muldoon (Richard Pryor) also uses the New Service throughout the film.
While dressed as the professor, Johnson (Stefan Gierasch) prepares an Armalite AR-18. During the junction shootout, both Devereau (Patrick McGoohan) and Johnson use AR-18s fitted with scopes. Caldwell (Gene Wilder) takes Johnson's AR-18 and fires at Devereau with it.
During the junction shootout, many of the FBI agents are armed with M16 rifles. A sharpshooter on a helicopter with Chief Donaldson (Len Birman) uses one to fire back at Devereau (who is on the train), only to be wounded by Devereau's AR-18. Donaldson later commandeers the weapon and fires at Devereau with it.
