FBI Agents Kate Mercer, Reggie Wayne ([[Daniel Kaluuya]]) and Phoenix Police Department SWAT officers use [[M4A1 Carbine|M4A1 Carbines]] during the film's opening raid in Chandler, AZ. DEA Agent Steve Forsing ([[Jeffrey Donovan]]) and Delta Force commandos also use M4A1 Carbines, as do Mexican Federal Police officers, Border Patrol Officers, and cartel members. At least one Phoenix SWAT officer wields a M4A1 with black Magpul MOE furniture in the first minute of the film before the raid as well as carried by Delta Force commandos notably by the team leader (Dylan Kenin) during the night raid to the tunnels in conjunction with the standard M4A1. Its possible these may be airsoft replicas as well but these rifles definitely feature 14.5 in barrels.
FBI Agents Kate Mercer, Reggie Wayne ([[Daniel Kaluuya]]) and Phoenix Police Department SWAT officers use [[M4A1 Carbine|M4A1 Carbines]] with EOTech 553 sights and/or Aimpoint CompM2 CCO sights during the film's opening raid in Chandler, AZ. DEA Agent Steve Forsing ([[Jeffrey Donovan]]) and Delta Force commandos also use M4A1 Carbines with EOTech 553 sights and foregrips. Mexican Federal Police officers, Border Patrol Officers, and cartel members carry M4A1s with detachable carrying handle rear iron sight and older A2 rounded handguards. At least two Phoenix SWAT officer wields a M4A1 with black Magpul MOE furniture and ACOG scope in the first minute of the film before the raid as well as carried by Delta Force commandos, most notably by the team leader (Dylan Kenin) during the night raid to the tunnels in conjunction with the standard M4A1. Its possible these may be airsoft replicas as well but these rifles definitely feature 14.5 in barrels.
[[Image:M4A1EOT.jpg|thumb|none|400px|M4A1 Carbine with EOTech 552.A65 Holographic sight and SureFire M951XM05 tactical light - 5.56x45mm]]
[[Image:M4A1EOT.jpg|thumb|none|400px|M4A1 Carbine with EOTech 552.A65 Holographic sight and SureFire M951XM05 tactical light - 5.56x45mm NATO]]
[[File:Sicario-M4-1.jpg|thumb|none|601px|FBI Special Agent Kate Macer ([[Emily Blunt]]) armed with the M4A1 during the opening operation.]]
[[File:Sicario-M4-1.jpg|thumb|none|601px|FBI Special Agent Kate Macer ([[Emily Blunt]]) armed with the M4A1 with a EOTech 553 during the opening operation.]]
[[File:Sicario_301.jpg|thumb|none|601px|Steve Forsing ([[Jeffrey Donovan]]) raises his M4A1. Note that the M4 bolt is locked back. Earlier in the scene shows Steve simply hasn't pressed the bolt catch release button as it is seen sticking out. ]]
[[File:Sicario-M4A1-2.jpg|thumb|none|601px|Steve aims the M4A1 with an EOTech sight and foregrip when confronting a group of hitmen near the border crossing. Here the bolt is closed indicating the rifle is chambered.]]
[[File:Sicario-92FS-1.jpg|thumb|none|600px|Delta Force operatives armed with the carbines open fire on a group of cartel gunmen.]]
[[File:Sicario-M4-4.jpg|thumb|none|600px|Kate armed with the M4A1 while infiltrating the drug smuggling tunnels.]]
[[File:Sicario-M4-2.jpg|thumb|none|600px|A Mexican Federal Police officer holds an M4A1 while in the convoy.]]
[[File:Sicario-M4-2.jpg|thumb|none|600px|A Mexican Federal Police officer holds an M4A1 while in the convoy.]]
[[File:Sicario_301.jpg|thumb|none|601px|On the left, Steve Forsing ([[Jeffrey Donovan]]) raises his M4A1. Note that the M4 dust cover is open, indicating that the chamber is clearly empty.]]
[[File:Sicario-M4A1-2.jpg|thumb|none|601px|Steve Forsing ([[Jeffrey Donovan]]) aims the M4A1 with an EOTech sight and foregrip when confronting a group of hitmen near the border crossing.]]
[[File:Sicario-92FS-1.jpg|thumb|none|600px|Delta Force operatives armed with the carbines open fire on a group of cartel gunmen.]]
[[File:Sicario-M4-3.jpg|thumb|none|600px|A Sonora cartel member carrying the carbine loads drugs into Silvio's car.]]
[[File:Sicario-M4-3.jpg|thumb|none|600px|A Sonora cartel member carrying the carbine loads drugs into Silvio's car.]]
[[File:Sicario-M4-4.jpg|thumb|none|600px|Kate armed with the M4A1 while infiltrating the drug smuggling tunnels.]]
[[File:M4A1 airsoft carbine Magpul black.JPG|thumb|none|400px|'''Airsoft''' M4A1 with Black Magpul furniture]]
[[File:M4A1 airsoft carbine Magpul black.JPG|thumb|none|400px|'''Airsoft''' M4A1 with Black Magpul furniture]]
[[File:Sicario-M4MOE-1.jpg|thumb|none|600px|The Delta team leader (Dylan Kenin) holds a G&P M4 MOE CQBR with an ACOG sight.]]
[[File:Sicario-M4MOE-1.jpg|thumb|none|600px|The Delta team leader (Dylan Kenin) holds a Magpul M4A1 with an ACOG sight.]]
Kate Macer (Emily Blunt) and other FBI agents carry a third generation Glock 19 as their main sidearm, the former notably using hers during the shootout at the Juárez-El Paso border crossing.
A Beretta 92FS can be seen in a Delta Force operator's holster during the shootout at the border crossing. A Sonora cartel member is later seen wielding a Beretta.
SIG-Sauer P226 DAK
A Sonora Cartel gunman uses a SIG-Sauer P226 DAK during the border crossing shootout.
FN Five-seveN
Manuel Diaz (Bernardo P. Sarancino) retrieves an FN Five-seveN USG when he is pulled over by the police.
Alejandro (Benicio del Toro) uses a Heckler & Koch MP5A3 with a Gemtech suppressor, KAC railed handguards and an Aimpoint sight. An unsuppressed MP5A3 with a Surefire forend is used by a cartel gunman during the border crossing shootout.
Heckler & Koch MP5SD3
Alejandro's MP5A3 becomes a Heckler & Koch MP5SD3 with an Aimpoint sight in non-firing scenes.
FBI Agents Kate Mercer, Reggie Wayne (Daniel Kaluuya) and Phoenix Police Department SWAT officers use M4A1 Carbines with EOTech 553 sights and/or Aimpoint CompM2 CCO sights during the film's opening raid in Chandler, AZ. DEA Agent Steve Forsing (Jeffrey Donovan) and Delta Force commandos also use M4A1 Carbines with EOTech 553 sights and foregrips. Mexican Federal Police officers, Border Patrol Officers, and cartel members carry M4A1s with detachable carrying handle rear iron sight and older A2 rounded handguards. At least two Phoenix SWAT officer wields a M4A1 with black Magpul MOE furniture and ACOG scope in the first minute of the film before the raid as well as carried by Delta Force commandos, most notably by the team leader (Dylan Kenin) during the night raid to the tunnels in conjunction with the standard M4A1. Its possible these may be airsoft replicas as well but these rifles definitely feature 14.5 in barrels.
Daniel Defense M4A1
Matt Graver (Josh Brolin) uses a Daniel Defense M4A1 with a foregrip, Magpul PMAG, EOTech 553 sight, and SureFire M720V RAID flashlight as his main weapon.
Colt Model 933
A Mexican Federal Police officer is seen wielding a Colt Model 933.
G&P M4 MOE CQBR
During the border shootout, Delta Force commandos use what are likely airsoft replica G&P M4 MOE CQBR rifles. Border Patrol and ICE Agents are also seen with these rifles as they are guarding a large group of captured immigrants.
Heckler & Koch G36C
One of the Delta Force commandos can be seen wielding a Heckler & Koch G36C with an EOTech sight.
AKMSU
One of the cartel gunmen at the border crossing wields an AKMSU.
AK-103
An AK-103 rifle (likely an American semi-auto clone such as the Arsenal SLR-107FR) is used by a cartel hitman disguised as a Federal police officer (or a corrupt Federal police officer doing jobs for the cartel) during the border crossing shootout. A similar rifle is also seen in Silvio's (Maximiliano Hernández) home.
AKMS (Shortened)
One of Fausto Alarcon's bodyguards uses a shortened AKMS rifle.
Remington 700 PSS
During the film's opening raid, a SWAT sniper uses a Remington 700 PSS to provide cover for Kate's team.
Machine Guns
FN M249E2 SAW
M249 SAW machine guns are mounted on Mexican Federal Police pickups.
M230 Chain Gun
The M230 Chain Gun is seen with AH-64 Apaches inside a US military base.
Shotguns
Mossberg 590 Mariner Cruiser
A member of the cartel uses a Mossberg 590 Mariner Cruiser during a shootout with the FBI.