[[Image:MP5A3RIS.jpg|thumb|none|400px|Heckler & Koch MP5-N with Navy trigger group, threaded muzzle, railed handguard, RIS foregrip, and M68 Aimpoint red dot scope - 9x19mm]]
[[Image:MP5A3RIS.jpg|thumb|none|400px|Heckler & Koch MP5-N with Navy trigger group, threaded muzzle, railed handguard, RIS foregrip, and M68 Aimpoint red dot scope - 9x19mm]]
[[File:ISS_01.jpg|thumb|none|400px|The screen used suppressed MP5A3 carried by Alejandro ([[Benicio del Toro]]) in the film ''[[Sicario]]'', from Independent Studio Services. (Video from Vickers Tactical).]]
[[File:Sicario-MP5-BTS.jpeg|thumb|none|400px|Production still of Alejandro ([[Benicio del Toro]]) aiming the MP5A3.]]
[[File:Sicario-MP5-BTS.jpeg|thumb|none|400px|Production still of Alejandro ([[Benicio del Toro]]) aiming the MP5A3.]]
[[File:Sicario-MP5-1.jpg|thumb|none|601px|Alejandro holds his suppressed MP5A3.]]
[[File:Sicario-MP5-1.jpg|thumb|none|601px|Alejandro holds his suppressed MP5A3.]]
[[File:Sicario-MP5-2.jpg|thumb|none|600px|]]
[[File:Sicario-MP5-2.jpg|thumb|none|600px|The MP5A3 held by Alejandro during the confrontation near the border.]]
[[File:Sicario-MP5-3.jpg|thumb|none|600px|]]
[[File:Sicario-MP5-3.jpg|thumb|none|600px|A night vision image of an operator with the weapon.]]
[[File:HKMP5A3.jpg|thumb|none|400px|Heckler & Koch MP5A3 with Surefire Weaponlight and "SD"-style stock.]]
[[File:HKMP5A3.jpg|thumb|none|400px|Heckler & Koch MP5A3 with Surefire Weaponlight and "SD"-style stock.]]
[[File:Sicario-MP5-4.jpg|thumb|none|600px|An unsuppressed MP5A3 with a Surefire forend is used by a cartel gunman during the border crossing shootout.]]
[[File:Sicario-MP5-4.jpg|thumb|none|600px|An unsuppressed MP5A3 with a Surefire forend is used by a cartel gunman during the border crossing shootout.]]
Kate Macer (Emily Blunt) and other FBI agents carry a third generation Glock 19 as their main sidearm, the former notably using hers during the shootout at the Juárez-El Paso border crossing.
A Beretta 92FS can be seen in a Delta Force operator's holster during the shootout at the border crossing. A Sonora cartel member is later seen wielding a Beretta.
SIG-Sauer P226 DAK
A Sonora Cartel gunman uses a SIG-Sauer P226 DAK during the border crossing shootout.
FN Five-seveN
Manuel Diaz (Bernardo P. Sarancino) retrieves an FN Five-seveN USG when he is pulled over by the police.
Alejandro (Benicio del Toro) uses a Heckler & Koch MP5A3 with a suppressor, railed handguards and an Aimpoint sight. An unsuppressed MP5A3 with a Surefire forend is used by a cartel gunman during the border crossing shootout.
Heckler & Koch MP5SD3
Alejandro's MP5A3 becomes a Heckler & Koch MP5SD3 with an Aimpoint sight in non-firing scenes.
Kate, Reggie Wayne (Daniel Kaluuya) and Phoenix PD SWAT officers use M4A1 Carbines during a raid. DEA Agent Steve Forsing (Jeffrey Donovan) and Delta Force commandos also use M4A1 Carbines, as do Mexican Federal Police officers, Border Patrol Officers, and cartel members. Note, Prior to the convoy shootout at the border crossing, as the teams are identifying the two threat targets, Jeffrey Donovan's M4 dust cover is open and the chamber is clearly empty.
Daniel Defense M4A1
Matt (Josh Brolin) uses a Daniel Defense DDM4 "M4A1" with a foregrip, Magpul PMAG and EOTech sight as his main weapon.
Colt Model 933
A Mexican Federal Police officer is seen wielding a Colt Model 933.
G&P M4 MOE CQBR
Delta Force commandos use what are likely airsoft G&P M4 MOE CQBR rifles throughout the film. Border Patrol and ICE Agents are also seen with these rifles as they are guarding a large group of captured immigrants.
Heckler & Koch G36C
One of the Delta Force commandos can be seen wielding a Heckler & Koch G36C with an EOTech sight.
AKMSU
One of the cartel gunmen at the border crossing wields an AKMSU.
AK-103
An AK-103 rifle (likely an American semi-auto clone such as the Arsenal SLR-103) is used by a cartel hitman disguised as a Federal police officer (or a corrupt Federal police officer doing jobs for the cartel) during the border crossing shootout. A similar rifle is also seen in Silvio's (Maximiliano Hernández) home.
AKMS (Shortened)
One of Fausto Alarcon's bodyguards uses a shortened AKMS rifle.
Remington 700 PSS
During the film's opening raid, a SWAT sniper uses a Remington 700 PSS to provide cover for Kate's team.
Machine Guns
FN M249E2 SAW
M249 SAW machine guns are mounted on Mexican Federal Police pickups.
Shotguns
Mossberg 590 Mariner Cruiser
A member of the cartel uses a Mossberg 590 Mariner Cruiser during a shootout with the FBI.